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• W2061330339 abstract "1. The proteolytic enzymes trypsin, pepsin, chymotrypsin, and to a lesser extent papain, are effective in separating single cells from rat Walker ascites tumour islands and adult rat liver cubes. None of the other enzymes used was effective. Trypsin inactivated with diisopropylfluorophosphate produces no separation of cells from either tissue. This supports previous suggestions that the intercellular material contains protein. 2. Artificial “tissues” made by agglutinting erythrocytes with synthetic basic polymers and protamine are partially separated by inactivated trypsin as well as active trypsin, and by pepsin but not chymotrypsin. The mechanism of separation, which does not involve enzymic action, is probably the interaction between the charged molecules of the enzymes and those of the agglutinating polymer, and does not appear to operate significantly in the naturally occurring tissues. 3. Artificial tissues made by agglutinating rat erythrocytes with immune rabbit γ-globulin are extremely resistant to disaggregation by the action of proteolytic enzymes. 4. It is suggested that the intercellular protein is not necessarily a basic protein, holding adjacent cells together solely by salt links, but it is less resistant to proteolytic digestion than rabbit γ-globulin. 5. Incubation of adult rat liver and the tumour islands with versene is no more effective in separating the cells than incubation with saline. No significant separation of adjacent liver cells could be detected in electron micrographs of sections of adult rat livers perfused with versene. It is suggested that the role of calcium in the cellular adhesiveness of these adult tissues has been overemphasized. 6. Incubation of rat and mouse erythrocytes and mouse Landschütz ascites tumour cells with a varity of enzymes does not have any effect, within the sensitivity of the technique employed, on the permeability of these cells to sodium chloride and glycerol. Most of the enzymes confer some slight protection on the cells against the action of a surface active agent, Lubrol W." @default.
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• W2061330339 date "1960-11-01" @default.
• W2061330339 modified "2023-10-17" @default.
• W2061330339 title "The nature of the intercellular material of adult mammalian tissues" @default.
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• W2061330339 doi "https://doi.org/10.1016/0014-4827(60)90269-x" @default.
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