FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061332707> ?p ?o ?g. }

• W2061332707 endingPage "299" @default.
• W2061332707 startingPage "290" @default.
• W2061332707 abstract "We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually induced this phenotype. Principal component analysis (PCA) using these probes clearly separated dose- and time-dependent clusters of treated groups from their controls. Moreover, 6 drugs (chloramphenicol, chlorpromazine, gentamicin, perhexiline, promethazine, and tamoxifen), which were reported to cause phospholipidosis but judged as negative by histopathological examination, were designated as positive by PCA using these probe sets. Eight drugs (carbon tetrachloride, coumarin, tetracycline, metformin, hydroxyzine, diltiazem, 2-bromoethylamine, and ethionamide), which showed phospholipidosis-like vacuolar formation in the histopathology, could be distinguished from the typical drugs causing phospholipidosis. Moreover, the possible induction of phospholipidosis was predictable by the expression of these genes 24 h after single administration in some of the drugs. We conclude that these identified 78 probe sets could be useful for diagnosis of phospholipidosis, and that toxicogenomics would be a promising approach for prediction of this type of toxicity." @default.
• W2061332707 created "2016-06-24" @default.
• W2061332707 creator A5020740301 @default.
• W2061332707 creator A5026030880 @default.
• W2061332707 creator A5032063684 @default.
• W2061332707 creator A5057502083 @default.
• W2061332707 creator A5060595394 @default.
• W2061332707 creator A5083093928 @default.
• W2061332707 date "2008-06-15" @default.
• W2061332707 modified "2023-10-17" @default.
• W2061332707 title "Gene expression profiling in rat liver treated with compounds inducing phospholipidosis" @default.
• W2061332707 cites W1429481766 @default.
• W2061332707 cites W1514511377 @default.
• W2061332707 cites W1548505084 @default.
• W2061332707 cites W1795186414 @default.
• W2061332707 cites W1966009072 @default.
• W2061332707 cites W1968037013 @default.
• W2061332707 cites W1970191094 @default.
• W2061332707 cites W1976576010 @default.
• W2061332707 cites W1978629640 @default.
• W2061332707 cites W1996469957 @default.
• W2061332707 cites W1997458334 @default.
• W2061332707 cites W2000766441 @default.
• W2061332707 cites W2014084301 @default.
• W2061332707 cites W2018250765 @default.
• W2061332707 cites W2021714714 @default.
• W2061332707 cites W2047808622 @default.
• W2061332707 cites W2057125222 @default.
• W2061332707 cites W2063055977 @default.
• W2061332707 cites W2070211560 @default.
• W2061332707 cites W2072471164 @default.
• W2061332707 cites W2088827589 @default.
• W2061332707 cites W2116342732 @default.
• W2061332707 cites W2122683221 @default.
• W2061332707 cites W2125373391 @default.
• W2061332707 cites W2156160866 @default.
• W2061332707 cites W2158646614 @default.
• W2061332707 cites W2171603185 @default.
• W2061332707 cites W2239879472 @default.
• W2061332707 cites W2403443435 @default.
• W2061332707 cites W2417742935 @default.
• W2061332707 cites W2469953515 @default.
• W2061332707 cites W2474280435 @default.
• W2061332707 cites W2394856876 @default.
• W2061332707 doi "https://doi.org/10.1016/j.taap.2008.01.036" @default.
• W2061332707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355885" @default.
• W2061332707 hasPublicationYear "2008" @default.
• W2061332707 type Work @default.
• W2061332707 sameAs 2061332707 @default.
• W2061332707 citedByCount "56" @default.
• W2061332707 countsByYear W20613327072012 @default.
• W2061332707 countsByYear W20613327072013 @default.
• W2061332707 countsByYear W20613327072014 @default.
• W2061332707 countsByYear W20613327072015 @default.
• W2061332707 countsByYear W20613327072016 @default.
• W2061332707 countsByYear W20613327072018 @default.
• W2061332707 countsByYear W20613327072019 @default.
• W2061332707 crossrefType "journal-article" @default.
• W2061332707 hasAuthorship W2061332707A5020740301 @default.
• W2061332707 hasAuthorship W2061332707A5026030880 @default.
• W2061332707 hasAuthorship W2061332707A5032063684 @default.
• W2061332707 hasAuthorship W2061332707A5057502083 @default.
• W2061332707 hasAuthorship W2061332707A5060595394 @default.
• W2061332707 hasAuthorship W2061332707A5083093928 @default.
• W2061332707 hasConcept C104317684 @default.
• W2061332707 hasConcept C150194340 @default.
• W2061332707 hasConcept C2778918659 @default.
• W2061332707 hasConcept C2779934242 @default.
• W2061332707 hasConcept C41625074 @default.
• W2061332707 hasConcept C55493867 @default.
• W2061332707 hasConcept C86803240 @default.
• W2061332707 hasConcept C93231420 @default.
• W2061332707 hasConcept C98274493 @default.
• W2061332707 hasConceptScore W2061332707C104317684 @default.
• W2061332707 hasConceptScore W2061332707C150194340 @default.
• W2061332707 hasConceptScore W2061332707C2778918659 @default.
• W2061332707 hasConceptScore W2061332707C2779934242 @default.
• W2061332707 hasConceptScore W2061332707C41625074 @default.
• W2061332707 hasConceptScore W2061332707C55493867 @default.
• W2061332707 hasConceptScore W2061332707C86803240 @default.
• W2061332707 hasConceptScore W2061332707C93231420 @default.
• W2061332707 hasConceptScore W2061332707C98274493 @default.
• W2061332707 hasIssue "3" @default.
• W2061332707 hasLocation W20613327071 @default.
• W2061332707 hasLocation W20613327072 @default.
• W2061332707 hasOpenAccess W2061332707 @default.
• W2061332707 hasPrimaryLocation W20613327071 @default.
• W2061332707 hasRelatedWork W1491941631 @default.
• W2061332707 hasRelatedWork W1591373009 @default.
• W2061332707 hasRelatedWork W1970470711 @default.
• W2061332707 hasRelatedWork W1986702471 @default.
• W2061332707 hasRelatedWork W2025019451 @default.
• W2061332707 hasRelatedWork W2075026871 @default.
• W2061332707 hasRelatedWork W2147123014 @default.
• W2061332707 hasRelatedWork W2514082913 @default.
• W2061332707 hasRelatedWork W2907020574 @default.
• W2061332707 hasRelatedWork W3088834846 @default.
• W2061332707 hasVolume "229" @default.

• next