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- W2061335334 endingPage "67" @default.
- W2061335334 startingPage "49" @default.
- W2061335334 abstract "Abstract Cancer chemoprevention employs agents that block, hinder, or reverse tumorigenesis to prevent malignancy. Several putative cancer chemopreventive agents promote apoptosis in transformed cells initiated in animal carcinogenesis models or identified in human subjects, and/or in tumor cells cultured in vitro . Consequently, apoptosis induction is increasingly valued as a biologically significant anticancer mechanism in the arena of chemoprevention. In vitro studies suggest that the permeabilization of mitochondrial membranes is an important mechanistic determinant associated with the apoptosis induced by these agents. Mitochondrial membrane permeabilization (MMP) may occur via the control of proapoptotic Bcl‐2 family members, and/or by the induction of the mitochondrial permeability transition. Both of these cell death‐inducing regulatory mechanisms are ultimately responsive to the bioenergetic status/redox state of mitochondria. Interestingly, in addition to inducing MMP, various chemopreventive agents can directly modulate mitochondrial bioenergetics and/or redox tone in transformed cells. This review will examine prospective mechanisms associated with the disruption of mitochondrial function by chemopreventive agents that affect MMP and apoptosis. In doing so, we will construct a paradigm supporting the notion that the bioenergetic and/or redox characteristics of the mitochondria in transformed cells are important targets in the chemoprevention of cancer." @default.
- W2061335334 created "2016-06-24" @default.
- W2061335334 creator A5063003854 @default.
- W2061335334 creator A5071506976 @default.
- W2061335334 date "2008-12-23" @default.
- W2061335334 modified "2023-10-12" @default.
- W2061335334 title "Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cells<i>via</i>the disruption of mitochondrial bioenergetics/redox state" @default.
- W2061335334 cites W1493048246 @default.
- W2061335334 cites W1512809204 @default.
- W2061335334 cites W1522763255 @default.
- W2061335334 cites W1550247880 @default.
- W2061335334 cites W1583699416 @default.
- W2061335334 cites W1593219141 @default.
- W2061335334 cites W1595972372 @default.
- W2061335334 cites W1605201556 @default.
- W2061335334 cites W1644794975 @default.
- W2061335334 cites W183275956 @default.
- W2061335334 cites W1950405118 @default.
- W2061335334 cites W1962219200 @default.
- W2061335334 cites W1967585926 @default.
- W2061335334 cites W1968262299 @default.
- W2061335334 cites W1968354566 @default.
- W2061335334 cites W1970508003 @default.
- W2061335334 cites W1972468918 @default.
- W2061335334 cites W1973058491 @default.
- W2061335334 cites W1973365570 @default.
- W2061335334 cites W1975009275 @default.
- W2061335334 cites W1975077780 @default.
- W2061335334 cites W1975364228 @default.
- W2061335334 cites W1975411070 @default.
- W2061335334 cites W1975421048 @default.
- W2061335334 cites W1976314402 @default.
- W2061335334 cites W1977037331 @default.
- W2061335334 cites W1977694127 @default.
- W2061335334 cites W1977955431 @default.
- W2061335334 cites W1978017125 @default.
- W2061335334 cites W1978052764 @default.
- W2061335334 cites W1981451401 @default.
- W2061335334 cites W1982284880 @default.
- W2061335334 cites W1983746805 @default.
- W2061335334 cites W1984862011 @default.
- W2061335334 cites W1985561510 @default.
- W2061335334 cites W1987711340 @default.
- W2061335334 cites W1988072297 @default.
- W2061335334 cites W1989114406 @default.
- W2061335334 cites W1991430141 @default.
- W2061335334 cites W1991963027 @default.
- W2061335334 cites W1994527193 @default.
- W2061335334 cites W1995935153 @default.
- W2061335334 cites W1997951817 @default.
- W2061335334 cites W1998089076 @default.
- W2061335334 cites W1999651862 @default.
- W2061335334 cites W2001254434 @default.
- W2061335334 cites W2002831133 @default.
- W2061335334 cites W2003679920 @default.
- W2061335334 cites W2005020033 @default.
- W2061335334 cites W2005027345 @default.
- W2061335334 cites W2005901733 @default.
- W2061335334 cites W2006591337 @default.
- W2061335334 cites W2007176967 @default.
- W2061335334 cites W2011690681 @default.
- W2061335334 cites W2011821957 @default.
- W2061335334 cites W2012230565 @default.
- W2061335334 cites W2012778598 @default.
- W2061335334 cites W2013028549 @default.
- W2061335334 cites W2013091489 @default.
- W2061335334 cites W2013716694 @default.
- W2061335334 cites W2013870734 @default.
- W2061335334 cites W2022627623 @default.
- W2061335334 cites W2023150880 @default.
- W2061335334 cites W2023217997 @default.
- W2061335334 cites W2023939312 @default.
- W2061335334 cites W2027156218 @default.
- W2061335334 cites W2027443731 @default.
- W2061335334 cites W2027601233 @default.
- W2061335334 cites W2027899494 @default.
- W2061335334 cites W2028556682 @default.
- W2061335334 cites W2031324765 @default.
- W2061335334 cites W2031496016 @default.
- W2061335334 cites W2033431239 @default.
- W2061335334 cites W2034564939 @default.
- W2061335334 cites W2037519959 @default.
- W2061335334 cites W2037871169 @default.
- W2061335334 cites W2039779394 @default.
- W2061335334 cites W2040663140 @default.
- W2061335334 cites W2041551776 @default.
- W2061335334 cites W2043287922 @default.
- W2061335334 cites W2043632706 @default.
- W2061335334 cites W2045059903 @default.
- W2061335334 cites W2045520547 @default.
- W2061335334 cites W2049406640 @default.
- W2061335334 cites W2050110236 @default.
- W2061335334 cites W2050451392 @default.
- W2061335334 cites W2053313807 @default.
- W2061335334 cites W2053499416 @default.
- W2061335334 cites W2056464864 @default.
- W2061335334 cites W2057523433 @default.
- W2061335334 cites W2061104433 @default.