FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061346387> ?p ?o ?g. }

• W2061346387 endingPage "546" @default.
• W2061346387 startingPage "540" @default.
• W2061346387 abstract "The aim of this work was to analyze the effect of Interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) on NADPH oxidase activity and gp91-phox gene expression in human colostrum macrophages (CM), peripheral blood monocytes (PBM), and myelomonocytic THP-1 cells. We also investigated the effect of IFN-γ on the release of TNF-α by these cells. Our results show that under basal culture conditions, CM release more superoxide than PBM and THP-1 cells (p < 0.05). The addition of IFN-γ, alone or in combination with TNF-α, increased spontaneous superoxide release by PBM and THP-1 cells (p < 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p < 0.05). The NADPH oxidase activity of THP-1 cells consistently remained lower than that of CM or PBM, despite a dramatic response to IFN-γ and TNF-α. Under basal conditions, gp91-phox gene expression was significantly higher in CM and PBM compared with THP-1 cells (p < 0.05). The addition of IFN-γ alone or in combination with TNF-α caused a dramatic increase in gp91-phox gene expression in THP-1 cells (p < 0.05) but not in CM or PBM. Under basal conditions or in the presence of IFN-γ, CM released more TNF-α than PBM or THP-1 cells (p < 0.05). In addition, PBM released more TNF-γ than THP-1 cells (p < 0.05). IFN-γ did not significantly augment the release of TNF-α by these cells (p > 0.05). Thus, IFN-γ and TNF-α induced equivalent gp91-phox gene expression in THP-1 cells compared with CM or PBM but did not bring about equivalent NADPH oxidase activity. TNF-α release was higher in more mature cells. This partial divergence of gp91- phox gene expression, NADPH oxidase activity, and TNF-α release is probably a consequence of different events of myeloid cell biology and relates at least in part to cell differentiation state." @default.
• W2061346387 created "2016-06-24" @default.
• W2061346387 creator A5024340841 @default.
• W2061346387 creator A5028805841 @default.
• W2061346387 creator A5065215242 @default.
• W2061346387 creator A5067646320 @default.
• W2061346387 creator A5090580248 @default.
• W2061346387 creator A5090911068 @default.
• W2061346387 date "2005-09-01" @default.
• W2061346387 modified "2023-10-03" @default.
• W2061346387 title "The Effect of IFN-γ and TNF-α on the NADPH Oxidase System of Human Colostrum Macrophages, Blood Monocytes, and THP-1 Cells" @default.
• W2061346387 cites W1512040448 @default.
• W2061346387 cites W1518731697 @default.
• W2061346387 cites W1579712238 @default.
• W2061346387 cites W1581967973 @default.
• W2061346387 cites W1604970632 @default.
• W2061346387 cites W1616455297 @default.
• W2061346387 cites W1940436875 @default.
• W2061346387 cites W1982925959 @default.
• W2061346387 cites W1989622726 @default.
• W2061346387 cites W1997384824 @default.
• W2061346387 cites W2017499162 @default.
• W2061346387 cites W2018834553 @default.
• W2061346387 cites W2023986228 @default.
• W2061346387 cites W2032510762 @default.
• W2061346387 cites W2039520117 @default.
• W2061346387 cites W2039927306 @default.
• W2061346387 cites W2047956396 @default.
• W2061346387 cites W2048486951 @default.
• W2061346387 cites W2052216327 @default.
• W2061346387 cites W2053611125 @default.
• W2061346387 cites W2062394657 @default.
• W2061346387 cites W2063222959 @default.
• W2061346387 cites W2068682899 @default.
• W2061346387 cites W2075382874 @default.
• W2061346387 cites W2076354748 @default.
• W2061346387 cites W2077093629 @default.
• W2061346387 cites W2102538853 @default.
• W2061346387 cites W2143272819 @default.
• W2061346387 cites W2147934559 @default.
• W2061346387 cites W2159767209 @default.
• W2061346387 cites W2162459367 @default.
• W2061346387 cites W2169979796 @default.
• W2061346387 cites W2176899369 @default.
• W2061346387 cites W2316421596 @default.
• W2061346387 cites W2352036364 @default.
• W2061346387 cites W4255385584 @default.
• W2061346387 cites W756957860 @default.
• W2061346387 doi "https://doi.org/10.1089/jir.2005.25.540" @default.
• W2061346387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16181054" @default.
• W2061346387 hasPublicationYear "2005" @default.
• W2061346387 type Work @default.
• W2061346387 sameAs 2061346387 @default.
• W2061346387 citedByCount "18" @default.
• W2061346387 countsByYear W20613463872012 @default.
• W2061346387 countsByYear W20613463872013 @default.
• W2061346387 countsByYear W20613463872014 @default.
• W2061346387 countsByYear W20613463872015 @default.
• W2061346387 countsByYear W20613463872016 @default.
• W2061346387 countsByYear W20613463872017 @default.
• W2061346387 countsByYear W20613463872019 @default.
• W2061346387 countsByYear W20613463872023 @default.
• W2061346387 crossrefType "journal-article" @default.
• W2061346387 hasAuthorship W2061346387A5024340841 @default.
• W2061346387 hasAuthorship W2061346387A5028805841 @default.
• W2061346387 hasAuthorship W2061346387A5065215242 @default.
• W2061346387 hasAuthorship W2061346387A5067646320 @default.
• W2061346387 hasAuthorship W2061346387A5090580248 @default.
• W2061346387 hasAuthorship W2061346387A5090911068 @default.
• W2061346387 hasConcept C134018914 @default.
• W2061346387 hasConcept C153911025 @default.
• W2061346387 hasConcept C17991360 @default.
• W2061346387 hasConcept C181199279 @default.
• W2061346387 hasConcept C185592680 @default.
• W2061346387 hasConcept C195794163 @default.
• W2061346387 hasConcept C203014093 @default.
• W2061346387 hasConcept C204258353 @default.
• W2061346387 hasConcept C2776178377 @default.
• W2061346387 hasConcept C2779719074 @default.
• W2061346387 hasConcept C2780043322 @default.
• W2061346387 hasConcept C2780795997 @default.
• W2061346387 hasConcept C2781184567 @default.
• W2061346387 hasConcept C48349386 @default.
• W2061346387 hasConcept C54355233 @default.
• W2061346387 hasConcept C55493867 @default.
• W2061346387 hasConcept C62478195 @default.
• W2061346387 hasConcept C81885089 @default.
• W2061346387 hasConcept C86803240 @default.
• W2061346387 hasConceptScore W2061346387C134018914 @default.
• W2061346387 hasConceptScore W2061346387C153911025 @default.
• W2061346387 hasConceptScore W2061346387C17991360 @default.
• W2061346387 hasConceptScore W2061346387C181199279 @default.
• W2061346387 hasConceptScore W2061346387C185592680 @default.
• W2061346387 hasConceptScore W2061346387C195794163 @default.
• W2061346387 hasConceptScore W2061346387C203014093 @default.
• W2061346387 hasConceptScore W2061346387C204258353 @default.
• W2061346387 hasConceptScore W2061346387C2776178377 @default.
• W2061346387 hasConceptScore W2061346387C2779719074 @default.

• next