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• W2061349441 endingPage "189" @default.
• W2061349441 startingPage "170" @default.
• W2061349441 abstract "CD8(+) T cells provide a major line of defense against intracellular pathogens. Upon encounter with antigen, CD8(+) T cells go through three distinct phases involving proliferation, contraction, and differentiation to become eventually long-lived CD8(+) memory T cells. CD8(+) memory T cells provide long-term protection against infection by intracellular pathogens. CD8(+) memory T-cell proliferation and survival are regulated by many factors, including cytokines, and CD8(+) memory T cells are stably maintained over a period of months to years. In aged humans and mice, however, there are significant alterations to the CD8(+) memory T-cell compartment with frequent development of monoclonal expansions of CD8(+) memory T cells in healthy individuals. Interestingly, CD8(+) clonal expansions are not malignant and do not progress to lymphomas, suggesting that these cells must still be under certain constraints. In this review, we discuss our current understanding of factors that contribute to and regulate these CD8(+) clonal expansions as well as the impact of CD8(+) clonal expansions on immune function of the aged. In addition, we discuss similarities and differences between CD8(+) clonal expansions observed in humans and mice, and we postulate that CD8(+) clonal expansions represent a spectrum of biological outcomes ranging from antigen-driven to antigen-independent phenomena." @default.
• W2061349441 created "2016-06-24" @default.
• W2061349441 creator A5014699103 @default.
• W2061349441 creator A5040853234 @default.
• W2061349441 creator A5044329784 @default.
• W2061349441 creator A5054609180 @default.
• W2061349441 date "2005-05-09" @default.
• W2061349441 modified "2023-10-12" @default.
• W2061349441 title "Non-malignant clonal expansions of CD8+ memory T cells in aged individuals" @default.
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