FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061353614> ?p ?o ?g. }

• W2061353614 abstract "Objective The aim of this study was to evaluate the effect of using pentoxifylline (PTX) and ketamine on serum levels of interleukin (IL)-6, IL-10, and malondialdehyde (MDA) during coronary artery bypass grafting surgery. Patients and methods The study included 60 patients, 39 men and 21 women, with a mean age of 48.6 ± 9.1 years and a mean ejection fraction (EF) of 56.7 ± 3.8%. Patients were randomly allocated into three equal groups: the control group received placebo infusion; the ketamine group received 0.5 mg/kg ketamine as an intravenous bolus dose administered after induction of anesthesia, followed by continuous infusion with 1.25 μg/kg/min ketamine until weaning from cardiopulmonary bypass (CPB); and the PTX group received 5 mg/kg PTX as an intravenous bolus dose administered after induction of anesthesia, followed by continuous infusion with 1.5 mg/kg/h PTX until weaning from CPB. Blood samples were collected from the patients after induction of anesthesia (baseline; T 0 ) and 4 h (T 1 ), 24 h (T 2 ), and 48 h (T 3 ) after aortic declamping for estimation of serum IL-6, IL-10, and MDA levels using ELISA. Results All patients showed a steadily progressive increase in serum IL-6 levels; however, both ketamine and PTX had a blunting effect on IL-6 release, manifested as nonsignificantly ( P 3 = 0.262 and 0.794, respectively) higher serum levels estimated at T 1 compared with T 0 , with significantly ( P 3 = 0.0006) lower levels compared with those in the control group. All patients showed significantly ( P 3 = 0.001, 0.005, and 0.028 in control, ketamine, and PTX groups, respectively) higher serum IL-6 levels at T 3 compared with T 2 , which were significantly ( P 3 = 0.0004, 0.0006, and 0.001 in control, ketamine, and PTX groups, respectively) higher than those at T 1 . The PTX group showed significantly lower IL-6 levels at T 2 compared with the ketamine group ( P 2 = 0.018). Serum IL-10 levels were significantly ( P 3 = 0.029, 0.0005, and 0.0007 in control, ketamine, and PTX groups, respectively) higher at T 1 compared with T 0 , with significantly higher levels in the ketamine ( P 1 = 0.031) and PTX ( P 1 = 0.0009) groups compared with the control group. Serum IL-10 levels were significantly higher in the control ( P 3 = 0.041), ketamine ( P 3 = 0.001), and PTX ( P 3 = 0.009) groups at T 2 compared with T 1 , with significantly higher levels in the ketamine ( P 1 = 0.0006) and PTX ( P 1 = 0.0007) groups compared with the control group and significantly higher levels in the PTX ( P 1 = 0.002) group compared with the ketamine group. Serum IL-10 levels were significantly lower in the control ( P 3 = 0.001) and ketamine ( P 3 = 0.0009) groups, with nonsignificantly lower ( P 3 = 0.136) levels in the PTX group, at T 3 compared with T 2 , with significantly higher levels in the ketamine ( P 1 = 0.002) and PTX ( P 1 = 0.0005) groups compared with the control group and significantly higher levels in the PTX ( P 1 = 0.0007) group compared with the ketamine group. Serum MDA levels were significantly ( P 3 = 0.0004, 0.0005, and 0.0004 in control, ketamine, and PTX groups, respectively) higher at T 1 compared with T 0 , with significantly higher levels in the ketamine ( P 1 = 0.021) and PTX ( P 1 = 0.0009) groups compared with the control group and significantly higher levels in the ketamine group ( P 2 = 0.001) compared with the PTX group. Serum MDA levels were significantly higher in the control ( P 3 = 0.006) and ketamine ( P 3 = 0.049) groups, but nonsignificantly higher in the PTX ( P 3 = 0.681) group, at T 2 compared with T 1 , with significantly lower levels in the PTX group ( P 1 = 0.003) and nonsignificantly ( P 1 = 0.219) lower levels in the ketamine group compared with the control group and significantly lower levels in the PTX ( P 2 = 0.002) group compared with the ketamine group. Serum MDA levels were nonsignificantly lower in the control ( P 3 = 0.732), ketamine ( P 3 = 0.164), and PTX ( P 3 = 0.128) groups at T 3 compared with T 2 , with nonsignificantly ( P 3 = 0.678) higher levels in the ketamine group but significantly higher ( P 1 = 0.003) levels in the PTX group compared with the control group and significantly lower levels in the PTX ( P 1 = 0.028) group compared with the ketamine group. Conclusion Using of PTX or ketamine could ameliorate the systemic inflammatory response, as well as oxidative stress response, in patients undergoing coronary artery bypass grafting with CPB and could shift the immune response to surgery toward the anti-inflammatory side. However, such effects were more pronounced with PTX than with ketamine." @default.
• W2061353614 created "2016-06-24" @default.
• W2061353614 creator A5059819109 @default.
• W2061353614 creator A5061047215 @default.
• W2061353614 date "2014-01-01" @default.
• W2061353614 modified "2023-09-27" @default.
• W2061353614 title "Pentoxifylline is better than ketamine in modulating the systemic inflammatory response in patients undergoing coronary artery bypass grafting" @default.
• W2061353614 cites W174672181 @default.
• W2061353614 cites W1995302690 @default.
• W2061353614 cites W2087633509 @default.
• W2061353614 cites W3023923910 @default.
• W2061353614 doi "https://doi.org/10.4103/1687-9090.137230" @default.
• W2061353614 hasPublicationYear "2014" @default.
• W2061353614 type Work @default.
• W2061353614 sameAs 2061353614 @default.
• W2061353614 citedByCount "0" @default.
• W2061353614 crossrefType "journal-article" @default.
• W2061353614 hasAuthorship W2061353614A5059819109 @default.
• W2061353614 hasAuthorship W2061353614A5061047215 @default.
• W2061353614 hasConcept C126322002 @default.
• W2061353614 hasConcept C141071460 @default.
• W2061353614 hasConcept C142724271 @default.
• W2061353614 hasConcept C204787440 @default.
• W2061353614 hasConcept C27081682 @default.
• W2061353614 hasConcept C2776151105 @default.
• W2061353614 hasConcept C2776820930 @default.
• W2061353614 hasConcept C2778401633 @default.
• W2061353614 hasConcept C2778789114 @default.
• W2061353614 hasConcept C2778881276 @default.
• W2061353614 hasConcept C2780404050 @default.
• W2061353614 hasConcept C2780655333 @default.
• W2061353614 hasConcept C2780795376 @default.
• W2061353614 hasConcept C42219234 @default.
• W2061353614 hasConcept C43376680 @default.
• W2061353614 hasConcept C71924100 @default.
• W2061353614 hasConceptScore W2061353614C126322002 @default.
• W2061353614 hasConceptScore W2061353614C141071460 @default.
• W2061353614 hasConceptScore W2061353614C142724271 @default.
• W2061353614 hasConceptScore W2061353614C204787440 @default.
• W2061353614 hasConceptScore W2061353614C27081682 @default.
• W2061353614 hasConceptScore W2061353614C2776151105 @default.
• W2061353614 hasConceptScore W2061353614C2776820930 @default.
• W2061353614 hasConceptScore W2061353614C2778401633 @default.
• W2061353614 hasConceptScore W2061353614C2778789114 @default.
• W2061353614 hasConceptScore W2061353614C2778881276 @default.
• W2061353614 hasConceptScore W2061353614C2780404050 @default.
• W2061353614 hasConceptScore W2061353614C2780655333 @default.
• W2061353614 hasConceptScore W2061353614C2780795376 @default.
• W2061353614 hasConceptScore W2061353614C42219234 @default.
• W2061353614 hasConceptScore W2061353614C43376680 @default.
• W2061353614 hasConceptScore W2061353614C71924100 @default.
• W2061353614 hasLocation W20613536141 @default.
• W2061353614 hasOpenAccess W2061353614 @default.
• W2061353614 hasPrimaryLocation W20613536141 @default.
• W2061353614 hasRelatedWork W2351796931 @default.
• W2061353614 hasRelatedWork W2354969731 @default.
• W2061353614 hasRelatedWork W2355371561 @default.
• W2061353614 hasRelatedWork W2358739924 @default.
• W2061353614 hasRelatedWork W2361463165 @default.
• W2061353614 hasRelatedWork W2363207377 @default.
• W2061353614 hasRelatedWork W2365061847 @default.
• W2061353614 hasRelatedWork W2366048146 @default.
• W2061353614 hasRelatedWork W2367154696 @default.
• W2061353614 hasRelatedWork W2376979552 @default.
• W2061353614 hasRelatedWork W2379355068 @default.
• W2061353614 hasRelatedWork W2381410383 @default.
• W2061353614 hasRelatedWork W2384578778 @default.
• W2061353614 hasRelatedWork W2386851569 @default.
• W2061353614 hasRelatedWork W2389074032 @default.
• W2061353614 hasRelatedWork W2389997379 @default.
• W2061353614 hasRelatedWork W2393948434 @default.
• W2061353614 hasRelatedWork W2394160008 @default.
• W2061353614 hasRelatedWork W3031249537 @default.
• W2061353614 hasRelatedWork W3031288678 @default.
• W2061353614 isParatext "false" @default.
• W2061353614 isRetracted "false" @default.
• W2061353614 magId "2061353614" @default.
• W2061353614 workType "article" @default.