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- W2061355916 abstract "Received August 11, 2011 Revised September 29, 2011 Accepted October 11, 2011 Address for correspondence Mi Kyung Ye, MD Department of OtorhinolaryngologyHead and Neck Surgery, College of Medicine, Catholic University of Daegu, 3056-6 Daemyeong 4-dong, Nam-gu, Daegu 705-718, Korea Tel +82-53-650-4525 Fax +82-53-650-4533 E-mail miky@cu.ac.kr Background and ObjectivesZZGenetic variations of bitter taste receptors (TAS2R) have shown different responses to bitter taste compounds and the frequencies of these variations were different within and between populations. Recently, single nucleotide polymorphisms (SNPs) in the TAS2R38 and TAS2R16 genes demonstrated a significant association with smoking and alcohol consumption in several studies. The aim of this study was to determine the relationship between bitter taste gene polymorphism and cigarette smoking and alcohol intake in Korean. Subjects and MethodZZOne hundred seventy four healthy normal volunteers were asked to fill in a questionnaire regarding demographic information, smoking history, frequency of alcohol intake. Peripheral blood samples were obtained for DNA extraction and genotyping. Single nucleotide polymorphisms were identified on the TAS2R38 and TAS2R16 genes. ResultsZZHaplotype analyses of the three SNPs inside the TAS2R38 gene allowed identifying of only two haplotypes that were associated with the non-taster phenotype (AVI homozygous) and the taster phenotype (PAV homozygous and PAV/AVI heterozygous). Common SNP within TAS2R16, which results in aminoacid change in the protein (K172N), is not demonstrated in this study. Smokers and frequent drinkers were more prevalent among non-tasters than tasters in male. ConclusionZZFunctional variants in TAS2R38 correlated with cigarette smoking in the Korean male. Our findings suggest that taster status plays a role in governing the development of nicotine dependence. Korean J Otorhinolaryngol-Head Neck Surg 2011;54:847-52" @default.
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- W2061355916 date "2011-01-01" @default.
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- W2061355916 title "Relationship between Taste Genotype and Smoking and Alcohol Intake" @default.
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- W2061355916 doi "https://doi.org/10.3342/kjorl-hns.2011.54.12.847" @default.
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