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• W2061359459 abstract "MicroRNAs (miRNAs) are short RNAs of about 22 nucleotides in length that post-transcriptionally regulate gene expression by binding to 3’ untranslated regions of mRNAs, thereby inducing translational silencing. Recently, more than 140 miRNAs have been identified in the genomes of herpesviruses. Deciphering their role in viral biology requires the identification of target genes, a challenging task because miRNAs require only limited complementarity. The subject of this review will be the herpesvirus miRNAs and their respective target genes that have been determined experimentally to date. These miRNAs regulate fundamental cellular processes including immunity, angiogenesis, apoptosis, and key steps in the herpesvirus life cycle, latency and the switch from latent to lytic replication. MicroRNAs (miRNAs) are short RNAs of about 22 nucleotides in length that post-transcriptionally regulate gene expression by binding to 3’ untranslated regions of mRNAs, thereby inducing translational silencing. Recently, more than 140 miRNAs have been identified in the genomes of herpesviruses. Deciphering their role in viral biology requires the identification of target genes, a challenging task because miRNAs require only limited complementarity. The subject of this review will be the herpesvirus miRNAs and their respective target genes that have been determined experimentally to date. These miRNAs regulate fundamental cellular processes including immunity, angiogenesis, apoptosis, and key steps in the herpesvirus life cycle, latency and the switch from latent to lytic replication. a 2’-O-methylated RNA oligonucleotide complementary to a specific miRNA that is used to inhibit miRNA function. a synthetic miRNA, delivered by transfection. an miRNA with transforming activity and/or upregulated in human cancer (e.g. miR-155 or miR-16). a small interfering RNA that binds with complete sequence complementarity to mRNAs and that induces RISC-dependent degradation." @default.
• W2061359459 created "2016-06-24" @default.
• W2061359459 creator A5032322535 @default.
• W2061359459 creator A5065570626 @default.
• W2061359459 creator A5070175640 @default.
• W2061359459 date "2009-12-01" @default.
• W2061359459 modified "2023-10-03" @default.
• W2061359459 title "Role of virus-encoded microRNAs in herpesvirus biology" @default.
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• W2061359459 doi "https://doi.org/10.1016/j.tim.2009.09.002" @default.
• W2061359459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2802859" @default.
• W2061359459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19828316" @default.
• W2061359459 hasPublicationYear "2009" @default.
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