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- W2061360015 abstract "Ro 15-4513 (1.5 mg/kg) decreased the exploratory activity of mice in a holeboard test. This effect was reversed by diazepam (1 mg/kg), ethanol (1 g/kg) and sodium pentobarbital (15 mg/kg). Higher doses of these three agents reduced the number of exploratory head-dips, and Ro 15-4513 antagonised these effects. These observations are consistent with the suggestion that Ro 15-4513 is a partial inverse agonist at benzodiazepine receptors and acts by reducing the efficacy of GABA. Ro 15-4513's interaction with ethanol in the holeboard closely resembled its interaction with the barbiturate." @default.
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- W2061360015 date "1987-09-01" @default.
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- W2061360015 title "Interactions of Ro 15-4513 with diazepam, sodium pentobarbital and ethanol in a holeboard test" @default.
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- W2061360015 doi "https://doi.org/10.1016/0091-3057(87)90015-3" @default.
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