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• W2061361446 abstract "No AccessJournal of UrologyPediatric Urology1 Jun 1997Urinary Excretion of Epidermal Growth Factor in Children with Reflux Nephropathy Ryuichiro Konda, Kiyohide Sakai, Shozo Ota, Atsushi Takeda, Naoki Chida, and Seiichi Orikasa Ryuichiro KondaRyuichiro Konda More articles by this author , Kiyohide SakaiKiyohide Sakai More articles by this author , Shozo OtaShozo Ota More articles by this author , Atsushi TakedaAtsushi Takeda More articles by this author , Naoki ChidaNaoki Chida More articles by this author , and Seiichi OrikasaSeiichi Orikasa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64763-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined urinary levels of epidermal growth factor in children with reflux nephropathy to evaluate the clinical significance of urinary epidermal growth factor. Materials and Methods: We studied 59 boys and 41 girls 3 to 15 years old with reflux nephropathy, and 64 boys and 36 girls 3 to 15 years old who were healthy. Levels of urinary epidermal growth factor were determined by sandwich enzyme immunoassay using spot urine samples. We also determined the levels of serum creatinine, urinary alpha 1-microglobulin and urinary microalbumin. Absolute values of function of the left and right kidneys were assessed by 99mtechnetium dimercapto-succinic acid (DMSA) uptake. Results: Levels of urinary epidermal growth factor gradually decreased with age in healthy children. There were low levels of urinary epidermal growth factor in 20 of the 44 patients (45%) with unilateral low DMSA uptake and 18 of the 19 (95%) with low total DMSA uptake (right and left uptakes). Urinary epidermal growth factor significantly correlated with serum creatinine (R = -0.702, p <0.0001), urinary alpha 1-microglobulin (R = -0.606, p <0.0001), urinary microalbumin (R = -0.708, p <0.0001) and total DMSA uptake (R = 0.744, p <0.0001). Conclusions: These results suggest that urinary epidermal growth factor may be a useful clinical tool to monitor functional nephron mass in children with reflux nephropathy. References 1 : Epidermal growth factor and the kidney. Ann. Rev. Physiol.1989; 51: 67. Google Scholar 2 : Physiological concentrations of human epidermal growth factor in biological fluids: use of a sensitive enzyme immunoassay. Clin. Chim. Acta1986; 158: 81. Google Scholar 3 : Renal origin of rat urinary epidermal growth factor. Reg. Pept.1984; 10: 37. Google Scholar 4 : Subnormal concentrations of urinary epidermal growth factor in patients with kidney disease. J. Clin. Endocr. Metab.1986; 62: 1180. Google Scholar 5 : Studies on reflux nephropathy-renal tubular and glomerular damage evaluated by various urinary indices. Jap. J. Urol.1993; 84: 364. Google Scholar 6 : Followup study of renal function in children with reflux nephropathy after resolution of vesicoureteral reflux. J. Urol.1997; 157: 975. Link, Google Scholar 7 : Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains. J. Immunol. Methods1996; 190: 61. Google Scholar 8 : Validity of sup 99m Tc dimercaptosuccinic acid renal uptake for an assessment of individual kidney function. J. Urol.1978; 119: 305. Abstract, Google Scholar 9 : Diagnostic evaluation of prenatally recognized dilated upper urinary tract. Prob. Urol.1994; 8: 460. Google Scholar 10 : Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res.1986; 14: 8427. Google Scholar 11 : Expression of epidermal growth factor and its receptor in normal and diseased kidney: an immunohistochemical and in situ hybridization study. Kidney Int.1996; 49: 656. Google Scholar 12 : In situ hybridization of prepro-epidermal growth factor in the mouse kidney. Amer. J. Physiol.1989; 256: F632. part 2. Google Scholar 13 : Epidermal growth factor in human urine from birth to puberty. J. Endocr. Metab.1985; 61: 997. Google Scholar 14 : Human urinary epidermal growth factor: effects of age, sex, and female endocrine status. Life Sci.1986; 39: 1879. Google Scholar 15 : Reduced urinary excretion of epidermal growth factor in incipient and overt diabetic nephropathy. Diabetic Med.1989; 6: 121. Google Scholar 16 : The progression of vesicoureteral reflux nephropathy. Ann. Int. Med.1980; 92: 776. Google Scholar 17 : Long-term followup of infants with gross vesicoureteral reflux. J. Urol., part 21992; 148: 1709. Abstract, Google Scholar 18 : Vesico-ureteric reflux and reflux nephropathy. Kidney Int.1993; 42: S80. Google Scholar 19 : Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetes. New Engl. J. Med.1984; 310: 356. Google Scholar From the Department of Urology, Tohoku University School of Medicine, Sendai, Japan.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKonda R, Sakai K, Ota S, Takeda A, Chida N, Sato H and Orikasa S (2018) SOLUBLE INTERLEUKIN-2 RECEPTOR IN CHILDREN WITH REFLUX NEPHROPATHYJournal of Urology, VOL. 159, NO. 2, (535-539), Online publication date: 1-Feb-1998. Volume 157Issue 6June 1997Page: 2282-2286 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Ryuichiro Konda More articles by this author Kiyohide Sakai More articles by this author Shozo Ota More articles by this author Atsushi Takeda More articles by this author Naoki Chida More articles by this author Seiichi Orikasa More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2061361446 title "Urinary Excretion of Epidermal Growth Factor in Children with Reflux Nephropathy" @default.
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