FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061369620> ?p ?o ?g. }

• W2061369620 endingPage "8734" @default.
• W2061369620 startingPage "8723" @default.
• W2061369620 abstract "Combination cancer therapy has emerged as crucial approach for achieving superior anti-cancer efficacy. In this study, we developed a strategy by localized co-delivery of PLK1shRNA/polylysine-modified polyethylenimine (PEI-Lys) complexes and doxorubicin (DOX) using biodegradable, thermosensitive PLGA-PEG-PLGA hydrogels for treatment of osteosarcoma. When incubated with osteosarcoma Saos-2 and MG-63 cells, the hydrogel containing PLK1shRNA/PEI-Lys and DOX displayed significant synergistic effects in promoting the apoptosis of osteosarcoma cells in vitro . After subcutaneous injection of the hydrogel containing PLK1shRNA/PEI-Lys and DOX beside the tumors of nude mice bearing osteosarcoma Saos-2 xenografts, the hydrogels exhibited superior antitumor efficacy in vivo compared to the hydrogels loaded with PLK1shRNA/PEI-Lys or DOX alone. It is noteworthy that the combination treatment in vivo led to almost complete suppression of tumor growth up to 16 days, significantly enhanced PLK1 silencing, higher apoptosis of tumor masses, as well as increased cell cycle regulation . Additionally, ex vivo histological analysis of major organs of the mice indicated that the localized treatments showed no obvious damage to the organs, suggesting lower systemic toxicity of the treatments. Therefore, the strategy of localized, sustained co-delivery of PLK1shRNA and DOX by using the biodegradable, injectable hydrogel may have potential for efficient clinical treatment of osteosarcoma." @default.
• W2061369620 created "2016-06-24" @default.
• W2061369620 creator A5001941506 @default.
• W2061369620 creator A5010491128 @default.
• W2061369620 creator A5040542464 @default.
• W2061369620 creator A5043992437 @default.
• W2061369620 creator A5045930233 @default.
• W2061369620 creator A5051361816 @default.
• W2061369620 creator A5058280163 @default.
• W2061369620 creator A5090253931 @default.
• W2061369620 date "2014-10-01" @default.
• W2061369620 modified "2023-10-17" @default.
• W2061369620 title "PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment" @default.
• W2061369620 cites W1558704041 @default.
• W2061369620 cites W1577854799 @default.
• W2061369620 cites W1584701845 @default.
• W2061369620 cites W1618299283 @default.
• W2061369620 cites W1647075334 @default.
• W2061369620 cites W1963773424 @default.
• W2061369620 cites W1965905029 @default.
• W2061369620 cites W1967525450 @default.
• W2061369620 cites W1967912613 @default.
• W2061369620 cites W1972000776 @default.
• W2061369620 cites W1972810259 @default.
• W2061369620 cites W1975776530 @default.
• W2061369620 cites W1976150153 @default.
• W2061369620 cites W1983820911 @default.
• W2061369620 cites W1986690159 @default.
• W2061369620 cites W1992018116 @default.
• W2061369620 cites W2003507585 @default.
• W2061369620 cites W2008124244 @default.
• W2061369620 cites W2011541591 @default.
• W2061369620 cites W2011551652 @default.
• W2061369620 cites W2016200917 @default.
• W2061369620 cites W2025540821 @default.
• W2061369620 cites W2030141189 @default.
• W2061369620 cites W2032866974 @default.
• W2061369620 cites W2040825881 @default.
• W2061369620 cites W2043179978 @default.
• W2061369620 cites W2046092321 @default.
• W2061369620 cites W2049659609 @default.
• W2061369620 cites W2053106146 @default.
• W2061369620 cites W2053193449 @default.
• W2061369620 cites W2053463223 @default.
• W2061369620 cites W2057257609 @default.
• W2061369620 cites W2058002880 @default.
• W2061369620 cites W2060835907 @default.
• W2061369620 cites W2061208808 @default.
• W2061369620 cites W2067403798 @default.
• W2061369620 cites W2067587422 @default.
• W2061369620 cites W2068608662 @default.
• W2061369620 cites W2068646871 @default.
• W2061369620 cites W2076183717 @default.
• W2061369620 cites W2078532650 @default.
• W2061369620 cites W207954835 @default.
• W2061369620 cites W2081341733 @default.
• W2061369620 cites W2085563400 @default.
• W2061369620 cites W2086034451 @default.
• W2061369620 cites W2094000814 @default.
• W2061369620 cites W2095073588 @default.
• W2061369620 cites W2097170827 @default.
• W2061369620 cites W2099581302 @default.
• W2061369620 cites W2112309180 @default.
• W2061369620 cites W2122347701 @default.
• W2061369620 cites W2130968156 @default.
• W2061369620 cites W2133753029 @default.
• W2061369620 cites W2135196225 @default.
• W2061369620 cites W2148077417 @default.
• W2061369620 cites W2148226658 @default.
• W2061369620 cites W2152324247 @default.
• W2061369620 cites W2166454694 @default.
• W2061369620 cites W2168496018 @default.
• W2061369620 cites W2170864244 @default.
• W2061369620 cites W2327625380 @default.
• W2061369620 cites W4211039187 @default.
• W2061369620 cites W4244970282 @default.
• W2061369620 doi "https://doi.org/10.1016/j.biomaterials.2014.06.045" @default.
• W2061369620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25017095" @default.
• W2061369620 hasPublicationYear "2014" @default.
• W2061369620 type Work @default.
• W2061369620 sameAs 2061369620 @default.
• W2061369620 citedByCount "130" @default.
• W2061369620 countsByYear W20613696202015 @default.
• W2061369620 countsByYear W20613696202016 @default.
• W2061369620 countsByYear W20613696202017 @default.
• W2061369620 countsByYear W20613696202018 @default.
• W2061369620 countsByYear W20613696202019 @default.
• W2061369620 countsByYear W20613696202020 @default.
• W2061369620 countsByYear W20613696202021 @default.
• W2061369620 countsByYear W20613696202022 @default.
• W2061369620 countsByYear W20613696202023 @default.
• W2061369620 crossrefType "journal-article" @default.
• W2061369620 hasAuthorship W2061369620A5001941506 @default.
• W2061369620 hasAuthorship W2061369620A5010491128 @default.
• W2061369620 hasAuthorship W2061369620A5040542464 @default.
• W2061369620 hasAuthorship W2061369620A5043992437 @default.
• W2061369620 hasAuthorship W2061369620A5045930233 @default.
• W2061369620 hasAuthorship W2061369620A5051361816 @default.

• next