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• W2061371569 abstract "The vesicles of certain glutamatergic terminals in the mammalian forebrain are replete with ionic zinc. It is believed that during synaptic transmission zinc is released, binds to receptors on the pre- or postsynaptic membranes, and hence acts as a neuromodulator. Although exogenous zinc modulates a wide variety of channels, whether synaptic zinc transits across the synaptic cleft and alters the response of channels has been difficult to establish. We will review the evidence for zinc as a neuromodulator and propose diagnostic criteria for establishing whether it is indeed one. Moreover, we will delineate alternative ways in which zinc might act at synapses." @default.
• W2061371569 created "2016-06-24" @default.
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• W2061371569 creator A5053771439 @default.
• W2061371569 date "2008-05-13" @default.
• W2061371569 modified "2023-09-24" @default.
• W2061371569 title "Is Zinc a Neuromodulator?" @default.
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• W2061371569 doi "https://doi.org/10.1126/stke.119re3" @default.
• W2061371569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2730821" @default.
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• W2061371569 hasPublicationYear "2008" @default.
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