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- W2061372369 abstract "The effects of a repetitive stress induced by anticipation of pain were studied on the following somato-vegetative parameters: monosynaptic reflex (H reflex), nociceptive flexion reflex (RIII reflex), heart rate and respiratory frequency, in normal trained volunteers. A progressive increase in heart rate and in respiratory frequency, as well as a facilitation in H reflex parallel to an inhibition of RIII reflex (threshold increased) were observed in all subjects as a function of repetition of stress during 45 min. At this moment, a double-blind injection of a strong dose of naloxone (4 mg) resulted in a rapid exacerbation in vegetative responses (tachycardia, polypnea) as well as in an increase in the facilitation of the H reflex, whereas the RIII reflex was dramatically facilitated (threshold decreased). In contrast, no significant change in these parameters was observed during placebo (saline) injection compared to a control situation (no injection). These data strongly suggest that endogenous opioids are involved in the phenomenon of stress-induced analgesia in man. Moreover, they show that the release of opiates in these conditions possibly modulates non-specific structures which are known to be activated during stress or emotion." @default.
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- W2061372369 date "1980-10-01" @default.
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- W2061372369 title "Electrophysiological evidence for a release of endogenous opiates in stress-induced‘Analgesia’ in man" @default.
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- W2061372369 doi "https://doi.org/10.1016/0006-8993(80)90755-6" @default.
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