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- W2061376564 abstract "The present study examined the regional differences in dopamine transporter binding sites and NMDA receptor complex binding based on autoradiographic images obtained in postmortem sections of human normal brain tissues. In middle-aged control tissues, high and comparable levels of [3H]CFT binding were observed in the caudate nucleus, putamen, and accumbens nucleus without significant alteration along the rostrocaudal axis and ventral and dorsal parts of these nuclei. In aging normal brain tissues, dopamine binding sites for [3H]CFT were significantly reduced in the caudate nucleus, putamen, and accumbens nucleus. l-[3H]Glutamate, [3H]MK-801, and [3H]glycine binding to the NMDA receptor complex was lower in aging brain tissues than in middle-aged controls. Significant correlation did occur between age and [3H]CFT binding and between age and l-[3H]glutamate, [3H]MK-801, and [3H]glycine binding sites. These results demonstrate that the basal ganglia have age-associated reductions in dopamine transporter uptake and NMDA receptors. These data support hypoactive activity of the NMDA receptor complex system with advancing age. The dopamine transporter uptake and NMDA receptors appear to be vulnerable to the aging process in the basal ganglia." @default.
- W2061376564 created "2016-06-24" @default.
- W2061376564 creator A5060773899 @default.
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- W2061376564 date "2001-10-01" @default.
- W2061376564 modified "2023-10-18" @default.
- W2061376564 title "Age-Related Changes in the N-Methyl-d-aspartate Receptor Binding Sites within the Human Basal Ganglia" @default.
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- W2061376564 cites W1966577099 @default.
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- W2061376564 doi "https://doi.org/10.1006/exnr.2001.7737" @default.
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