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• W2061376616 endingPage "403" @default.
• W2061376616 startingPage "394" @default.
• W2061376616 abstract "Calcitonin gene related peptide (CGRP) is a vasodilator. Its plasma levels are altered in several human diseases, including migraine, hypertension and diabetes. CGRP is locally released by motor neurons, and is overexpressed in response to surgical or pharmacological blockage of neuromuscular transmission. Additionally to a brief discussion with regard to the clinical relevance of CGRP, this review focuses on the effects of CGRP on skeletal muscle excitation-contraction (EC) coupling, as well as the corresponding pathohysiological consequences. EC coupling involves activation of 2 different types of calcium channels: dihydropyridine receptors (DHPRs) located at the sarcolemma, and ryanodine receptors (RyR1s) located at the sarcoplasmic reticulum (SR). In response to electrical depolarization, DHPRs activate nearby and physically bound RyR1s, allowing Ca2+ from the SR to move into the cytosol (termed voltage-gated Ca2+ release, or VGCR). We recently found that CGRP stimulates VGCR by 350 % in as short as 1h. This effect, which lasts for at least 48 h, is due to activation of the CGRP receptor, and requires activation of the cAMP/PKA signaling pathway. CGRP also increases the amplitude of caffeine-induced Ca2+ release (400 %); suggesting increased SR Ca2+ content underlies stimulation of VGCR. Interestingly, in the long-term CGRP also increases the density of sarcolemmal DHPRs (up to 30%, within 24-48 h). We propose that these CGRP effects may contribute to prevent and/or restore symptoms in central core disease (CCD); a congenital myopathy that is linked to mutations in the gene encoding RyR1. Keywords: Calcitonin-gene-related peptide, excitation-contraction coupling, calcium channels, neuromuscular junction, central core disease, dihydropyridine receptor, ryanodine receptor, intracellular calcium" @default.
• W2061376616 created "2016-06-24" @default.
• W2061376616 creator A5062641790 @default.
• W2061376616 creator A5085119624 @default.
• W2061376616 date "2010-05-01" @default.
• W2061376616 modified "2023-10-18" @default.
• W2061376616 title "CGRP, a Vasodilator Neuropeptide that Stimulates Neuromuscular Transmission and EC Coupling" @default.
• W2061376616 cites W1438911412 @default.
• W2061376616 cites W150672633 @default.
• W2061376616 cites W1532984521 @default.
• W2061376616 cites W1542299656 @default.
• W2061376616 cites W1542795311 @default.
• W2061376616 cites W1553663192 @default.
• W2061376616 cites W1588748174 @default.
• W2061376616 cites W1591270417 @default.
• W2061376616 cites W1616840880 @default.
• W2061376616 cites W1753272189 @default.
• W2061376616 cites W183853873 @default.
• W2061376616 cites W1964831127 @default.
• W2061376616 cites W1968842550 @default.
• W2061376616 cites W1969517735 @default.
• W2061376616 cites W1970754745 @default.
• W2061376616 cites W1972010931 @default.
• W2061376616 cites W1972583385 @default.
• W2061376616 cites W1974399131 @default.
• W2061376616 cites W1974727511 @default.
• W2061376616 cites W1974749992 @default.
• W2061376616 cites W1976465185 @default.
• W2061376616 cites W1978394249 @default.
• W2061376616 cites W1981578013 @default.
• W2061376616 cites W1981753053 @default.
• W2061376616 cites W1985002041 @default.
• W2061376616 cites W1985988350 @default.
• W2061376616 cites W1986008678 @default.
• W2061376616 cites W1986338276 @default.
• W2061376616 cites W1988922803 @default.
• W2061376616 cites W1994460905 @default.
• W2061376616 cites W1994695193 @default.
• W2061376616 cites W1997050207 @default.
• W2061376616 cites W2001479401 @default.
• W2061376616 cites W2003904908 @default.
• W2061376616 cites W2004309582 @default.
• W2061376616 cites W2004442028 @default.
• W2061376616 cites W2007598552 @default.
• W2061376616 cites W2010043377 @default.
• W2061376616 cites W2010873798 @default.
• W2061376616 cites W2011307895 @default.
• W2061376616 cites W2015631486 @default.
• W2061376616 cites W2016154943 @default.
• W2061376616 cites W2019423772 @default.
• W2061376616 cites W2019591295 @default.
• W2061376616 cites W2023255886 @default.
• W2061376616 cites W2026520758 @default.
• W2061376616 cites W2030666707 @default.
• W2061376616 cites W2031081542 @default.
• W2061376616 cites W2031182153 @default.
• W2061376616 cites W2032733634 @default.
• W2061376616 cites W2033066280 @default.
• W2061376616 cites W2033413175 @default.
• W2061376616 cites W2035036972 @default.
• W2061376616 cites W2037658512 @default.
• W2061376616 cites W2038606768 @default.
• W2061376616 cites W2040177399 @default.
• W2061376616 cites W2042747855 @default.
• W2061376616 cites W2042885920 @default.
• W2061376616 cites W2043324458 @default.
• W2061376616 cites W2043407795 @default.
• W2061376616 cites W2047524454 @default.
• W2061376616 cites W2049409248 @default.
• W2061376616 cites W2049952900 @default.
• W2061376616 cites W2051018818 @default.
• W2061376616 cites W2054392530 @default.
• W2061376616 cites W2058261855 @default.
• W2061376616 cites W2058303999 @default.
• W2061376616 cites W2064222866 @default.
• W2061376616 cites W2069380892 @default.
• W2061376616 cites W2069811680 @default.
• W2061376616 cites W2075881946 @default.
• W2061376616 cites W2076035614 @default.
• W2061376616 cites W2079777126 @default.
• W2061376616 cites W2080232509 @default.
• W2061376616 cites W2083905297 @default.
• W2061376616 cites W2085550628 @default.
• W2061376616 cites W2085717356 @default.
• W2061376616 cites W2086727023 @default.
• W2061376616 cites W2091994202 @default.
• W2061376616 cites W2092093577 @default.
• W2061376616 cites W2095968162 @default.
• W2061376616 cites W2096592787 @default.
• W2061376616 cites W2099875514 @default.
• W2061376616 cites W2103750607 @default.
• W2061376616 cites W2108358725 @default.
• W2061376616 cites W2111112233 @default.
• W2061376616 cites W2114710946 @default.
• W2061376616 cites W2115263783 @default.
• W2061376616 cites W2117309485 @default.
• W2061376616 cites W2117375754 @default.
• W2061376616 cites W2119187582 @default.

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