FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061386749> ?p ?o ?g. }

• W2061386749 endingPage "8715" @default.
• W2061386749 startingPage "8708" @default.
• W2061386749 abstract "Abstract Loss of SEMA3F occurs frequently in lung cancer and correlates with advanced stage of disease. We previously reported that SEMA3F blocked tumor formation by H157 lung cancer cells in a rat orthotopic model. This was associated with loss of activated αVβ3 integrin, impaired cell adhesion to extracellular matrix components, and down-regulation of phospho-extracellular signal-regulated kinase 1/2 (ERK1/2). These results suggested that SEMA3F might interfere with integrin outside-in signaling. In the present report, we found that SEMA3F decreased adhesion to vitronectin, whereas integrin-linked kinase (ILK) kinase activity was down-regulated in SEMA3F-expressing H157 cells. Exposure to SEMA3F-conditioned medium led to diminution of phospho-ERK1/2 in four of eight lung cancer cell lines, and ILK silencing by small interfering RNA led to similar loss of phospho-ERK1/2 in H157 cells. Moreover, SEMA3F expression (with constitutive and inducible systems) also reduced AKT and signal transducer and activator of transcription 3 (STAT3) phosphorylation independently of ILK-ERK1/2. These signaling changes extended downstream to hypoxia-inducible factor-1α (HIF-1α) protein and vascular endothelial growth factor (VEGF) mRNA levels, which were both reduced in three of four SEMA3F-transfected cell lines. Mechanistically, the effects on HIF-1α were consistent with inhibition of its AKT-driven protein translation initiation, with no effect on HIF-1α mRNA level or protein degradation. Furthermore, when H157 cells were injected s.c. in nude mice, tumors derived from SEMA3F-expressing cells showed lower microvessel density and tumor growth. These results show that SEMA3F negatively affects ILK-ERK1/2 and AKT-STAT3 signaling, along with inhibition of HIF-1α and VEGF. These changes would be anticipated to contribute significantly to the observed antitumor activity of SEMA3F. [Cancer Res 2007;67(18):8708–15]" @default.
• W2061386749 created "2016-06-24" @default.
• W2061386749 creator A5015278948 @default.
• W2061386749 creator A5033305983 @default.
• W2061386749 creator A5033335642 @default.
• W2061386749 creator A5040794955 @default.
• W2061386749 creator A5045979335 @default.
• W2061386749 creator A5050325622 @default.
• W2061386749 creator A5051433948 @default.
• W2061386749 creator A5087213703 @default.
• W2061386749 date "2007-09-15" @default.
• W2061386749 modified "2023-10-15" @default.
• W2061386749 title "Semaphorin SEMA3F Affects Multiple Signaling Pathways in Lung Cancer Cells" @default.
• W2061386749 cites W1595029695 @default.
• W2061386749 cites W1607743413 @default.
• W2061386749 cites W1964361550 @default.
• W2061386749 cites W1965206733 @default.
• W2061386749 cites W1973186217 @default.
• W2061386749 cites W1976626500 @default.
• W2061386749 cites W1982317652 @default.
• W2061386749 cites W1988698986 @default.
• W2061386749 cites W1992925170 @default.
• W2061386749 cites W1993266290 @default.
• W2061386749 cites W1995280612 @default.
• W2061386749 cites W1998542470 @default.
• W2061386749 cites W2008182675 @default.
• W2061386749 cites W2021806172 @default.
• W2061386749 cites W2024774077 @default.
• W2061386749 cites W2029734659 @default.
• W2061386749 cites W2033116719 @default.
• W2061386749 cites W2041700814 @default.
• W2061386749 cites W2041756868 @default.
• W2061386749 cites W2045027538 @default.
• W2061386749 cites W2050108686 @default.
• W2061386749 cites W2055261266 @default.
• W2061386749 cites W2060136332 @default.
• W2061386749 cites W2067817921 @default.
• W2061386749 cites W2080374319 @default.
• W2061386749 cites W2082180864 @default.
• W2061386749 cites W2096643761 @default.
• W2061386749 cites W2098200708 @default.
• W2061386749 cites W2101484235 @default.
• W2061386749 cites W2102600622 @default.
• W2061386749 cites W2118719170 @default.
• W2061386749 cites W2131444119 @default.
• W2061386749 cites W2148357240 @default.
• W2061386749 cites W2167622058 @default.
• W2061386749 cites W2171588859 @default.
• W2061386749 cites W4230023006 @default.
• W2061386749 cites W4239907137 @default.
• W2061386749 doi "https://doi.org/10.1158/0008-5472.can-06-3612" @default.
• W2061386749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17875711" @default.
• W2061386749 hasPublicationYear "2007" @default.
• W2061386749 type Work @default.
• W2061386749 sameAs 2061386749 @default.
• W2061386749 citedByCount "67" @default.
• W2061386749 countsByYear W20613867492012 @default.
• W2061386749 countsByYear W20613867492013 @default.
• W2061386749 countsByYear W20613867492014 @default.
• W2061386749 countsByYear W20613867492015 @default.
• W2061386749 countsByYear W20613867492016 @default.
• W2061386749 countsByYear W20613867492017 @default.
• W2061386749 countsByYear W20613867492018 @default.
• W2061386749 countsByYear W20613867492019 @default.
• W2061386749 countsByYear W20613867492020 @default.
• W2061386749 countsByYear W20613867492021 @default.
• W2061386749 countsByYear W20613867492022 @default.
• W2061386749 countsByYear W20613867492023 @default.
• W2061386749 crossrefType "journal-article" @default.
• W2061386749 hasAuthorship W2061386749A5015278948 @default.
• W2061386749 hasAuthorship W2061386749A5033305983 @default.
• W2061386749 hasAuthorship W2061386749A5033335642 @default.
• W2061386749 hasAuthorship W2061386749A5040794955 @default.
• W2061386749 hasAuthorship W2061386749A5045979335 @default.
• W2061386749 hasAuthorship W2061386749A5050325622 @default.
• W2061386749 hasAuthorship W2061386749A5051433948 @default.
• W2061386749 hasAuthorship W2061386749A5087213703 @default.
• W2061386749 hasBestOaLocation W20613867491 @default.
• W2061386749 hasConcept C142724271 @default.
• W2061386749 hasConcept C171958077 @default.
• W2061386749 hasConcept C184235292 @default.
• W2061386749 hasConcept C2776256026 @default.
• W2061386749 hasConcept C2778923194 @default.
• W2061386749 hasConcept C502942594 @default.
• W2061386749 hasConcept C62478195 @default.
• W2061386749 hasConcept C66417403 @default.
• W2061386749 hasConcept C71924100 @default.
• W2061386749 hasConcept C75217442 @default.
• W2061386749 hasConcept C82495950 @default.
• W2061386749 hasConcept C86803240 @default.
• W2061386749 hasConcept C95444343 @default.
• W2061386749 hasConcept C97029542 @default.
• W2061386749 hasConceptScore W2061386749C142724271 @default.
• W2061386749 hasConceptScore W2061386749C171958077 @default.
• W2061386749 hasConceptScore W2061386749C184235292 @default.
• W2061386749 hasConceptScore W2061386749C2776256026 @default.
• W2061386749 hasConceptScore W2061386749C2778923194 @default.
• W2061386749 hasConceptScore W2061386749C502942594 @default.

• next