Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061394329> ?p ?o ?g. }
- W2061394329 endingPage "97" @default.
- W2061394329 startingPage "83" @default.
- W2061394329 abstract "Structural homogeneity of cardiac tissue is governed by mechanical and humoral factors that regulate cell growth, apoptosis, phenotype, and extracellular matrix turnover. ANGII has endocrine, autocrine, and paracrine properties that influence the behavior of cardiac cells and matrix by AT1 receptor binding. Various paradigms have been suggested, including ANGII-mediated up-regulation of collagen types I and III formation and deposition in cardiac conditions, such as HHD. A growing body of evidence, however, deals with the potential role of aldosterone, either local or systemic, in inducing cardiac fibrosis. Aldosterone might also mediate the profibrotic actions of ANGII. To reduce the risk of heart failure that accompanies HHD, its adverse structural remodeling (eg, myocardial hypertrophy and fibrosis) must be targeted for pharmacologic intervention. Cardioprotective agents must reverse not only the exaggerated growth of cardiac cells, but also regress existing abnormalities in fibrillar collagen. Available experimental and clinical data suggest that agents interfering with ACE, the AT1 receptor, or the mineralocorticoid receptor may provide such a cardioprotective effect." @default.
- W2061394329 created "2016-06-24" @default.
- W2061394329 creator A5003344321 @default.
- W2061394329 creator A5034591578 @default.
- W2061394329 creator A5066609762 @default.
- W2061394329 date "2004-01-01" @default.
- W2061394329 modified "2023-10-18" @default.
- W2061394329 title "Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system" @default.
- W2061394329 cites W124358902 @default.
- W2061394329 cites W1510586846 @default.
- W2061394329 cites W1957375239 @default.
- W2061394329 cites W1964436833 @default.
- W2061394329 cites W1964825408 @default.
- W2061394329 cites W1965524726 @default.
- W2061394329 cites W1965569454 @default.
- W2061394329 cites W1968604238 @default.
- W2061394329 cites W1970102552 @default.
- W2061394329 cites W1974777700 @default.
- W2061394329 cites W1976853286 @default.
- W2061394329 cites W1977152294 @default.
- W2061394329 cites W1987089303 @default.
- W2061394329 cites W1988137752 @default.
- W2061394329 cites W1988215184 @default.
- W2061394329 cites W1996163407 @default.
- W2061394329 cites W2000088166 @default.
- W2061394329 cites W2006296467 @default.
- W2061394329 cites W2013658571 @default.
- W2061394329 cites W2015582757 @default.
- W2061394329 cites W2022852324 @default.
- W2061394329 cites W2031203524 @default.
- W2061394329 cites W2031341816 @default.
- W2061394329 cites W2032165714 @default.
- W2061394329 cites W2032512398 @default.
- W2061394329 cites W2033565692 @default.
- W2061394329 cites W2037590681 @default.
- W2061394329 cites W2039359299 @default.
- W2061394329 cites W2044427990 @default.
- W2061394329 cites W2045149387 @default.
- W2061394329 cites W2049042331 @default.
- W2061394329 cites W2050202539 @default.
- W2061394329 cites W2051732956 @default.
- W2061394329 cites W2052645366 @default.
- W2061394329 cites W2054320666 @default.
- W2061394329 cites W2058050148 @default.
- W2061394329 cites W2063670795 @default.
- W2061394329 cites W2065972506 @default.
- W2061394329 cites W2076561457 @default.
- W2061394329 cites W2080924078 @default.
- W2061394329 cites W2083834362 @default.
- W2061394329 cites W2086832765 @default.
- W2061394329 cites W2088738437 @default.
- W2061394329 cites W2089392247 @default.
- W2061394329 cites W2093009414 @default.
- W2061394329 cites W2093594772 @default.
- W2061394329 cites W2095811222 @default.
- W2061394329 cites W2101201730 @default.
- W2061394329 cites W2102318592 @default.
- W2061394329 cites W2104357833 @default.
- W2061394329 cites W2106493153 @default.
- W2061394329 cites W2106761396 @default.
- W2061394329 cites W2109177794 @default.
- W2061394329 cites W2110712518 @default.
- W2061394329 cites W2115713362 @default.
- W2061394329 cites W2122004333 @default.
- W2061394329 cites W2124405902 @default.
- W2061394329 cites W2125557867 @default.
- W2061394329 cites W2126196465 @default.
- W2061394329 cites W2134264965 @default.
- W2061394329 cites W2134730025 @default.
- W2061394329 cites W2139688938 @default.
- W2061394329 cites W2140739392 @default.
- W2061394329 cites W2142393775 @default.
- W2061394329 cites W2144218866 @default.
- W2061394329 cites W2148635987 @default.
- W2061394329 cites W2151974006 @default.
- W2061394329 cites W2153981371 @default.
- W2061394329 cites W2154064433 @default.
- W2061394329 cites W2154684959 @default.
- W2061394329 cites W2155975134 @default.
- W2061394329 cites W2156941071 @default.
- W2061394329 cites W2163991033 @default.
- W2061394329 cites W2164224373 @default.
- W2061394329 cites W2164969601 @default.
- W2061394329 cites W2168453807 @default.
- W2061394329 cites W2169095915 @default.
- W2061394329 cites W2170032817 @default.
- W2061394329 cites W2171160325 @default.
- W2061394329 cites W2171836508 @default.
- W2061394329 cites W2172016508 @default.
- W2061394329 cites W2314029408 @default.
- W2061394329 cites W2323637528 @default.
- W2061394329 cites W23844702 @default.
- W2061394329 cites W4230586869 @default.
- W2061394329 doi "https://doi.org/10.1016/s0025-7125(03)00125-1" @default.
- W2061394329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14871052" @default.
- W2061394329 hasPublicationYear "2004" @default.
- W2061394329 type Work @default.
- W2061394329 sameAs 2061394329 @default.