Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061409925> ?p ?o ?g. }
- W2061409925 endingPage "3635" @default.
- W2061409925 startingPage "3635" @default.
- W2061409925 abstract "CAL-B catalyzed desymmetrization of prochiral 3-alkylglutaric acid diesters was performed to prepare optically active 3-alkylglutaric acid monoesters bearing various alkyl substituents, including methyl, ethyl, propyl and allyl groups. Allyl esters showed far better stereoselectivity among the alkyl esters, suggesting possible π–π interactions between the olefin of the substrate and the Trp104 or His224 side chains at the enzyme active site. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (pregabalin) was achieved with a 70% overall yield." @default.
- W2061409925 created "2016-06-24" @default.
- W2061409925 creator A5003331679 @default.
- W2061409925 creator A5033542712 @default.
- W2061409925 creator A5033835790 @default.
- W2061409925 creator A5060544438 @default.
- W2061409925 creator A5060736765 @default.
- W2061409925 creator A5069430902 @default.
- W2061409925 date "2013-01-01" @default.
- W2061409925 modified "2023-09-26" @default.
- W2061409925 title "CAL-B catalyzed desymmetrization of 3-alkylglutarate: “olefin effect” and asymmetric synthesis of pregabalin" @default.
- W2061409925 cites W1964485400 @default.
- W2061409925 cites W1969750999 @default.
- W2061409925 cites W1969951206 @default.
- W2061409925 cites W1973395192 @default.
- W2061409925 cites W1977037639 @default.
- W2061409925 cites W1986394801 @default.
- W2061409925 cites W1987985385 @default.
- W2061409925 cites W1988456660 @default.
- W2061409925 cites W2000008094 @default.
- W2061409925 cites W2008662383 @default.
- W2061409925 cites W2011040374 @default.
- W2061409925 cites W2027408247 @default.
- W2061409925 cites W2032871998 @default.
- W2061409925 cites W2033495093 @default.
- W2061409925 cites W2034441468 @default.
- W2061409925 cites W2039438415 @default.
- W2061409925 cites W2048631643 @default.
- W2061409925 cites W2053150460 @default.
- W2061409925 cites W2056043668 @default.
- W2061409925 cites W2060336620 @default.
- W2061409925 cites W2081076124 @default.
- W2061409925 cites W2084207297 @default.
- W2061409925 cites W2085168700 @default.
- W2061409925 cites W2094966898 @default.
- W2061409925 cites W2112548852 @default.
- W2061409925 cites W2117569373 @default.
- W2061409925 cites W2119913545 @default.
- W2061409925 cites W2152517257 @default.
- W2061409925 cites W2152775636 @default.
- W2061409925 cites W2158713664 @default.
- W2061409925 cites W2165489120 @default.
- W2061409925 cites W2167507361 @default.
- W2061409925 cites W2318876907 @default.
- W2061409925 cites W2330733968 @default.
- W2061409925 cites W2332184575 @default.
- W2061409925 cites W2953363467 @default.
- W2061409925 cites W4210988199 @default.
- W2061409925 cites W4240620708 @default.
- W2061409925 doi "https://doi.org/10.1039/c3ob40311d" @default.
- W2061409925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23525234" @default.
- W2061409925 hasPublicationYear "2013" @default.
- W2061409925 type Work @default.
- W2061409925 sameAs 2061409925 @default.
- W2061409925 citedByCount "22" @default.
- W2061409925 countsByYear W20614099252013 @default.
- W2061409925 countsByYear W20614099252014 @default.
- W2061409925 countsByYear W20614099252015 @default.
- W2061409925 countsByYear W20614099252016 @default.
- W2061409925 countsByYear W20614099252017 @default.
- W2061409925 countsByYear W20614099252019 @default.
- W2061409925 countsByYear W20614099252020 @default.
- W2061409925 countsByYear W20614099252021 @default.
- W2061409925 countsByYear W20614099252022 @default.
- W2061409925 countsByYear W20614099252023 @default.
- W2061409925 crossrefType "journal-article" @default.
- W2061409925 hasAuthorship W2061409925A5003331679 @default.
- W2061409925 hasAuthorship W2061409925A5033542712 @default.
- W2061409925 hasAuthorship W2061409925A5033835790 @default.
- W2061409925 hasAuthorship W2061409925A5060544438 @default.
- W2061409925 hasAuthorship W2061409925A5060736765 @default.
- W2061409925 hasAuthorship W2061409925A5069430902 @default.
- W2061409925 hasConcept C111368507 @default.
- W2061409925 hasConcept C127313418 @default.
- W2061409925 hasConcept C134121241 @default.
- W2061409925 hasConcept C146686406 @default.
- W2061409925 hasConcept C161790260 @default.
- W2061409925 hasConcept C178790620 @default.
- W2061409925 hasConcept C181647583 @default.
- W2061409925 hasConcept C185592680 @default.
- W2061409925 hasConcept C191897082 @default.
- W2061409925 hasConcept C192562407 @default.
- W2061409925 hasConcept C2777190055 @default.
- W2061409925 hasConcept C2777289219 @default.
- W2061409925 hasConcept C2780263894 @default.
- W2061409925 hasConcept C3019471444 @default.
- W2061409925 hasConcept C51886252 @default.
- W2061409925 hasConcept C71240020 @default.
- W2061409925 hasConceptScore W2061409925C111368507 @default.
- W2061409925 hasConceptScore W2061409925C127313418 @default.
- W2061409925 hasConceptScore W2061409925C134121241 @default.
- W2061409925 hasConceptScore W2061409925C146686406 @default.
- W2061409925 hasConceptScore W2061409925C161790260 @default.
- W2061409925 hasConceptScore W2061409925C178790620 @default.
- W2061409925 hasConceptScore W2061409925C181647583 @default.
- W2061409925 hasConceptScore W2061409925C185592680 @default.
- W2061409925 hasConceptScore W2061409925C191897082 @default.
- W2061409925 hasConceptScore W2061409925C192562407 @default.