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• W2061417619 abstract "OBJECTIVES To examine the operative findings, histopathology and clinical outcome of patients undergoing repeat retroperitoneal lymph node dissection (RPLND) after initial chemotherapy and RPLND (PC‐RPLND) for metastatic testicular germ cell tumour (GCT), as a small proportion relapse or have residual disease after incomplete resection in the lung, retrocrural or pelvic nodes, and retroperitoneum. PATIENTS AND METHODS Between September 1992 and May 2006, 359 patients had PC‐RPLND under the care of one surgeon, 54 of which were repeat procedures. We compared the long‐term outcome between those having primary and those having repeat PC‐RPLND. RESULTS The median (range) time from original to repeat surgery was 2.4 (0.25–26.5) years, and the median follow‐up after the repeat procedure was 5.8 (0.08–12.9) years. There was no difference in survival between patients requiring only one PC‐RPLND and those having a repeat procedure ( P = 0.592). The most frequent sites of recurrent disease were: behind the great vessels/para‐aortic areas (38, 46%), in the suprahilar region (18, 18%), in the retrocrural area (16, 19%), in the pelvic nodes (10, 12%) and in the lung (one, 1%). The most common pathological findings in the repeat PC‐RPLNDs were differentiated teratoma (19, 35%), malignant teratoma undifferentiated (nine, 17%), adenocarcinoma (eight, 15%) and necrotic tissue (five, 9.2%). CONCLUSION Although a small proportion of patients with metastatic GCT might require repeat PC‐RPLND, there is no difference in survival between this group and those having one PC‐RPLND. However, to avoid cancer recurrence and reoperation, it is crucial that the first PC‐RPLND is careful and complete, preferably done in a centre with expertise in this procedure." @default.
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• W2061417619 date "2007-08-17" @default.
• W2061417619 modified "2023-10-18" @default.
• W2061417619 title "Repeat retroperitoneal lymph-node dissection after chemotherapy for metastatic testicular germ cell tumour" @default.
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• W2061417619 doi "https://doi.org/10.1111/j.1464-410x.2007.07087.x" @default.
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