FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061420080> ?p ?o ?g. }

• W2061420080 endingPage "557" @default.
• W2061420080 startingPage "553" @default.
• W2061420080 abstract "Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the retrobulbar circulation. All these show that verapamil is potentially useful for ophthalmic treatment. Thus, the aim of this study is to investigate whether verapamil could protect human lens epithelial cell (HLEC) from oxidative stress induced by H2O2 and the cellular mechanism underlying this protective function. The viability of HLEC was determined by the MTT assay and apoptotic cell death was analyzed by Hoechst 33258 staining. Moreover, Caspase-3 expression was detected by immunocytochemistry and flow cytometry analysis. We also detected Caspase-3 mRNA expression by reverse-transcription-polymerase chain reaction and the GSH content in cell culture. The results showed that oxidative stress produced significant cell apoptotic death and it was reduced by previous treatment with the verapamil. Verapamil was effective in reducing HLEC death mainly through reducing the expression level of apoptosis-related proteins, caspase-3, and increasing glutathione content. Therefore, it was suggested that verapamil was effective in reducing HLEC apoptosis induced by H2O2." @default.
• W2061420080 created "2016-06-24" @default.
• W2061420080 creator A5016841529 @default.
• W2061420080 creator A5038805449 @default.
• W2061420080 creator A5053955970 @default.
• W2061420080 creator A5054056420 @default.
• W2061420080 date "2014-11-30" @default.
• W2061420080 modified "2023-10-18" @default.
• W2061420080 title "Protective Effects of Verapamil against H₂O₂-Induced Apoptosis in Human Lens Epithelial Cells" @default.
• W2061420080 cites W1936380547 @default.
• W2061420080 cites W1964719154 @default.
• W2061420080 cites W1969887535 @default.
• W2061420080 cites W1970206930 @default.
• W2061420080 cites W1972678927 @default.
• W2061420080 cites W1974851337 @default.
• W2061420080 cites W1975807493 @default.
• W2061420080 cites W1983055388 @default.
• W2061420080 cites W1991865867 @default.
• W2061420080 cites W1996158201 @default.
• W2061420080 cites W2004329409 @default.
• W2061420080 cites W2010031618 @default.
• W2061420080 cites W2026098936 @default.
• W2061420080 cites W2036373599 @default.
• W2061420080 cites W2067943520 @default.
• W2061420080 cites W2070828755 @default.
• W2061420080 cites W2071625904 @default.
• W2061420080 cites W2078198885 @default.
• W2061420080 cites W2090122042 @default.
• W2061420080 cites W2134954483 @default.
• W2061420080 cites W2146296415 @default.
• W2061420080 doi "https://doi.org/10.4062/biomolther.2014.033" @default.
• W2061420080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256036" @default.
• W2061420080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25489424" @default.
• W2061420080 hasPublicationYear "2014" @default.
• W2061420080 type Work @default.
• W2061420080 sameAs 2061420080 @default.
• W2061420080 citedByCount "13" @default.
• W2061420080 countsByYear W20614200802015 @default.
• W2061420080 countsByYear W20614200802016 @default.
• W2061420080 countsByYear W20614200802017 @default.
• W2061420080 countsByYear W20614200802018 @default.
• W2061420080 countsByYear W20614200802019 @default.
• W2061420080 countsByYear W20614200802020 @default.
• W2061420080 countsByYear W20614200802021 @default.
• W2061420080 crossrefType "journal-article" @default.
• W2061420080 hasAuthorship W2061420080A5016841529 @default.
• W2061420080 hasAuthorship W2061420080A5038805449 @default.
• W2061420080 hasAuthorship W2061420080A5053955970 @default.
• W2061420080 hasAuthorship W2061420080A5054056420 @default.
• W2061420080 hasBestOaLocation W20614200802 @default.
• W2061420080 hasConcept C126322002 @default.
• W2061420080 hasConcept C153911025 @default.
• W2061420080 hasConcept C185592680 @default.
• W2061420080 hasConcept C190283241 @default.
• W2061420080 hasConcept C2776151105 @default.
• W2061420080 hasConcept C2777022698 @default.
• W2061420080 hasConcept C2780783641 @default.
• W2061420080 hasConcept C31573885 @default.
• W2061420080 hasConcept C35866371 @default.
• W2061420080 hasConcept C519063684 @default.
• W2061420080 hasConcept C53227056 @default.
• W2061420080 hasConcept C553184892 @default.
• W2061420080 hasConcept C55493867 @default.
• W2061420080 hasConcept C71924100 @default.
• W2061420080 hasConcept C86803240 @default.
• W2061420080 hasConcept C98274493 @default.
• W2061420080 hasConceptScore W2061420080C126322002 @default.
• W2061420080 hasConceptScore W2061420080C153911025 @default.
• W2061420080 hasConceptScore W2061420080C185592680 @default.
• W2061420080 hasConceptScore W2061420080C190283241 @default.
• W2061420080 hasConceptScore W2061420080C2776151105 @default.
• W2061420080 hasConceptScore W2061420080C2777022698 @default.
• W2061420080 hasConceptScore W2061420080C2780783641 @default.
• W2061420080 hasConceptScore W2061420080C31573885 @default.
• W2061420080 hasConceptScore W2061420080C35866371 @default.
• W2061420080 hasConceptScore W2061420080C519063684 @default.
• W2061420080 hasConceptScore W2061420080C53227056 @default.
• W2061420080 hasConceptScore W2061420080C553184892 @default.
• W2061420080 hasConceptScore W2061420080C55493867 @default.
• W2061420080 hasConceptScore W2061420080C71924100 @default.
• W2061420080 hasConceptScore W2061420080C86803240 @default.
• W2061420080 hasConceptScore W2061420080C98274493 @default.
• W2061420080 hasIssue "6" @default.
• W2061420080 hasLocation W20614200801 @default.
• W2061420080 hasLocation W20614200802 @default.
• W2061420080 hasLocation W20614200803 @default.
• W2061420080 hasLocation W20614200804 @default.
• W2061420080 hasOpenAccess W2061420080 @default.
• W2061420080 hasPrimaryLocation W20614200801 @default.
• W2061420080 hasRelatedWork W1979461875 @default.
• W2061420080 hasRelatedWork W2164509469 @default.
• W2061420080 hasRelatedWork W2358273413 @default.
• W2061420080 hasRelatedWork W2360919160 @default.
• W2061420080 hasRelatedWork W2362948099 @default.
• W2061420080 hasRelatedWork W2554658078 @default.
• W2061420080 hasRelatedWork W3032579496 @default.
• W2061420080 hasRelatedWork W4288700672 @default.
• W2061420080 hasRelatedWork W4307179377 @default.

• next