Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061425474> ?p ?o ?g. }
- W2061425474 endingPage "e25402" @default.
- W2061425474 startingPage "e25402" @default.
- W2061425474 abstract "The 5-year survival rate for oral cavity cancer is poorer than for breast, colon or prostate cancer, and has improved only slightly in the last three decades. Hence, new therapeutic strategies are urgently needed. Here we demonstrate by tissue micro array analysis for the first time that RNA-binding protein La is significantly overexpressed in oral squamous cell carcinoma (SCC). Within this study we therefore addressed the question whether siRNA-mediated depletion of the La protein may interfere with known tumor-promoting characteristics of head and neck SCC cells. Our studies demonstrate that the La protein promotes cell proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells. We also reveal that La is required for the expression of β-catenin as well as matrix metalloproteinase type 2 (MMP-2) within these cells. Taken together these data suggest a so far unknown function of the RNA-binding protein La in promoting tumor progression of head and neck SCC." @default.
- W2061425474 created "2016-06-24" @default.
- W2061425474 creator A5002404553 @default.
- W2061425474 creator A5013372221 @default.
- W2061425474 creator A5026021617 @default.
- W2061425474 creator A5070231960 @default.
- W2061425474 creator A5083938208 @default.
- W2061425474 date "2011-10-10" @default.
- W2061425474 modified "2023-10-03" @default.
- W2061425474 title "Implication of RNA-Binding Protein La in Proliferation, Migration and Invasion of Lymph Node-Metastasized Hypopharyngeal SCC Cells" @default.
- W2061425474 cites W1498968686 @default.
- W2061425474 cites W1510413462 @default.
- W2061425474 cites W1526567499 @default.
- W2061425474 cites W1582424095 @default.
- W2061425474 cites W1598867832 @default.
- W2061425474 cites W1611419331 @default.
- W2061425474 cites W1727070404 @default.
- W2061425474 cites W1796970559 @default.
- W2061425474 cites W1943317391 @default.
- W2061425474 cites W1966223894 @default.
- W2061425474 cites W1969330771 @default.
- W2061425474 cites W1970159404 @default.
- W2061425474 cites W1975954840 @default.
- W2061425474 cites W1977514824 @default.
- W2061425474 cites W1978506977 @default.
- W2061425474 cites W1984548528 @default.
- W2061425474 cites W1986848782 @default.
- W2061425474 cites W1986863362 @default.
- W2061425474 cites W1988076106 @default.
- W2061425474 cites W1991561242 @default.
- W2061425474 cites W1992885568 @default.
- W2061425474 cites W1997994746 @default.
- W2061425474 cites W2003593097 @default.
- W2061425474 cites W2005334224 @default.
- W2061425474 cites W2006344771 @default.
- W2061425474 cites W2010622983 @default.
- W2061425474 cites W2017352677 @default.
- W2061425474 cites W2020830322 @default.
- W2061425474 cites W2027858199 @default.
- W2061425474 cites W2028721376 @default.
- W2061425474 cites W2035081378 @default.
- W2061425474 cites W2041677910 @default.
- W2061425474 cites W2041703851 @default.
- W2061425474 cites W2044863150 @default.
- W2061425474 cites W2068652698 @default.
- W2061425474 cites W2073918272 @default.
- W2061425474 cites W2082024168 @default.
- W2061425474 cites W2089193547 @default.
- W2061425474 cites W2094185359 @default.
- W2061425474 cites W2097946485 @default.
- W2061425474 cites W2100592123 @default.
- W2061425474 cites W2101995865 @default.
- W2061425474 cites W2102518477 @default.
- W2061425474 cites W2106787323 @default.
- W2061425474 cites W2115768394 @default.
- W2061425474 cites W2119312493 @default.
- W2061425474 cites W2123114542 @default.
- W2061425474 cites W2123657381 @default.
- W2061425474 cites W2128212057 @default.
- W2061425474 cites W2135306934 @default.
- W2061425474 cites W2139308694 @default.
- W2061425474 cites W2141978988 @default.
- W2061425474 cites W2144829286 @default.
- W2061425474 cites W2156656162 @default.
- W2061425474 cites W2169696386 @default.
- W2061425474 cites W2171338297 @default.
- W2061425474 cites W2201991444 @default.
- W2061425474 cites W2397257832 @default.
- W2061425474 doi "https://doi.org/10.1371/journal.pone.0025402" @default.
- W2061425474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3189910" @default.
- W2061425474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22016766" @default.
- W2061425474 hasPublicationYear "2011" @default.
- W2061425474 type Work @default.
- W2061425474 sameAs 2061425474 @default.
- W2061425474 citedByCount "43" @default.
- W2061425474 countsByYear W20614254742012 @default.
- W2061425474 countsByYear W20614254742013 @default.
- W2061425474 countsByYear W20614254742014 @default.
- W2061425474 countsByYear W20614254742015 @default.
- W2061425474 countsByYear W20614254742016 @default.
- W2061425474 countsByYear W20614254742017 @default.
- W2061425474 countsByYear W20614254742018 @default.
- W2061425474 countsByYear W20614254742019 @default.
- W2061425474 countsByYear W20614254742020 @default.
- W2061425474 countsByYear W20614254742021 @default.
- W2061425474 countsByYear W20614254742022 @default.
- W2061425474 countsByYear W20614254742023 @default.
- W2061425474 crossrefType "journal-article" @default.
- W2061425474 hasAuthorship W2061425474A5002404553 @default.
- W2061425474 hasAuthorship W2061425474A5013372221 @default.
- W2061425474 hasAuthorship W2061425474A5026021617 @default.
- W2061425474 hasAuthorship W2061425474A5070231960 @default.
- W2061425474 hasAuthorship W2061425474A5083938208 @default.
- W2061425474 hasBestOaLocation W20614254741 @default.
- W2061425474 hasConcept C104317684 @default.
- W2061425474 hasConcept C121608353 @default.
- W2061425474 hasConcept C126322002 @default.
- W2061425474 hasConcept C137738243 @default.