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- W2061426858 abstract "In Brief Cyclooxygenase-1 (COX-1) inhibition by a selective inhibitor valeryl salicylate, or nonselective inhibitors at 10 mg/kg, including aspirin, ibuprofen, indomethacin, and picroxicam, attenuated by 29%-46% the duration of loss of righting reflex induced by diazepam (20 mg/kg) in mice. On the other hand, arachidonic acid (20 mg/kg) increased the duration of diazepam-induced loss of righting reflex by 48%. This effect of arachidonic acid was abolished by aspirin. However, aspirin at 10 mg/kg also did not alter the effects of diazepam (5 mg/kg) on spontaneous activity and rotarod performance. These findings strongly suggest that one or more COX products, most likely prostaglandins, play a significant role in modulating the hypnotic effect of diazepam. Elucidating the mechanism involved may further our understanding of the pharmacology of benzodiazepines. IMPLICATIONS: The finding that cyclooxygenase-1 inhibition decreases diazepam-induced loss of righting reflex in mice may warrant clinical trials to study the potential implications for the clinical use of benzodiazepines in patients taking nonsteroidal antiinflammatory drugs for a prolonged period of time." @default.
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- W2061426858 date "2006-01-01" @default.
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- W2061426858 title "Cyclooxygenase-1 Inhibition Shortens the Duration of Diazepam-Induced Loss of Righting Reflex in Mice" @default.
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- W2061426858 doi "https://doi.org/10.1213/01.ane.0000189102.09347.2e" @default.
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