FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061430064> ?p ?o ?g. }

• W2061430064 endingPage "712" @default.
• W2061430064 startingPage "701" @default.
• W2061430064 abstract "Aims The clinical relevance of expression of chemokine receptor 4 ( CXCR 4) in colorectal carcinoma ( CRC ) remains controversial; our aim was to identify the precise relationship of CXCR 4 to prognosis and clinicopathological features. Methods and results A meta‐analysis was performed. Original data included the hazard ratios ( HR s) of recurrence‐free survival ( RFS ), overall survival ( OS ) and odds ratio ( OR ) in CRC patients. We pooled HR / OR with 95% confidence intervals ( CI s) to estimate the hazard. A total of 20 published studies (including 2253 patients) were eligible. RFS and OS were related significantly to CXCR 4 expression, with HR s 1.62 (95% CI 1.24–2.11; P < 0.0001) and 1.68 (95% CI 1.31–2.14; P < 0.0001), respectively. In addition, a significant association was revealed between positive CXCR 4 expression and age (less than median age: OR 0.78, 95% CI 0.62–0.98; P = 0.03), stage ( I and II : OR 0.46, 95% CI 0.32–0.66; P < 0.0001), grade (well/moderately differentiated: OR 0.74, 95% CI 0.56–0.98; P = 0.04), location (colon: OR : 0.73, 95% CI 0.57–0.95; P = 0.02), lymph node invasion (present: OR 2.14, 95% CI 1.36–3.37; P = 0.001),and distant metastasis (present: OR 2.40; 95% CI 1.36–4.23; P = 0.003). Heterogeneity was observed among the included studies with regard to stage ( I 2 = 58 %), lymph node invasiveness ( I 2 = 74%) and distant metastasis ( I 2 = 56%). No publication bias was observed. Conclusions Chemokine receptor 4 expression indicates poorer prognosis in older patients and advanced stage or poor differentiation in CRC , and also serves as an indicator of lymph node and distal organ metastasis. Surprisingly, high CXCR 4 expression may indicate that the location of the tumour is the rectum. Thus, CXCR 4 could help to predict outcome and guide clinical therapy." @default.
• W2061430064 created "2016-06-24" @default.
• W2061430064 creator A5002590827 @default.
• W2061430064 creator A5015432344 @default.
• W2061430064 creator A5020931362 @default.
• W2061430064 creator A5043793009 @default.
• W2061430064 creator A5051570381 @default.
• W2061430064 creator A5083356558 @default.
• W2061430064 creator A5089820455 @default.
• W2061430064 creator A5090202478 @default.
• W2061430064 date "2014-01-15" @default.
• W2061430064 modified "2023-10-03" @default.
• W2061430064 title "The association of CXCR4 expression with prognosis and clinicopathological indicators in colorectal carcinoma patients: a meta-analysis" @default.
• W2061430064 cites W1534965809 @default.
• W2061430064 cites W1927423808 @default.
• W2061430064 cites W1964435302 @default.
• W2061430064 cites W1970266315 @default.
• W2061430064 cites W1980475208 @default.
• W2061430064 cites W1980884563 @default.
• W2061430064 cites W1990176468 @default.
• W2061430064 cites W1991126375 @default.
• W2061430064 cites W2001901391 @default.
• W2061430064 cites W2002403202 @default.
• W2061430064 cites W2019526813 @default.
• W2061430064 cites W2028299022 @default.
• W2061430064 cites W2030196526 @default.
• W2061430064 cites W2037044297 @default.
• W2061430064 cites W2040695812 @default.
• W2061430064 cites W2047763902 @default.
• W2061430064 cites W2056502071 @default.
• W2061430064 cites W2056874077 @default.
• W2061430064 cites W2057730609 @default.
• W2061430064 cites W2064312538 @default.
• W2061430064 cites W2065383116 @default.
• W2061430064 cites W2075642745 @default.
• W2061430064 cites W2081921364 @default.
• W2061430064 cites W2092692876 @default.
• W2061430064 cites W2094573329 @default.
• W2061430064 cites W2103970768 @default.
• W2061430064 cites W2108353340 @default.
• W2061430064 cites W2121245276 @default.
• W2061430064 cites W2121707125 @default.
• W2061430064 cites W2143604929 @default.
• W2061430064 cites W2151463502 @default.
• W2061430064 cites W2157823046 @default.
• W2061430064 cites W2159483382 @default.
• W2061430064 doi "https://doi.org/10.1111/his.12321" @default.
• W2061430064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24422942" @default.
• W2061430064 hasPublicationYear "2014" @default.
• W2061430064 type Work @default.
• W2061430064 sameAs 2061430064 @default.
• W2061430064 citedByCount "23" @default.
• W2061430064 countsByYear W20614300642014 @default.
• W2061430064 countsByYear W20614300642015 @default.
• W2061430064 countsByYear W20614300642016 @default.
• W2061430064 countsByYear W20614300642017 @default.
• W2061430064 countsByYear W20614300642018 @default.
• W2061430064 countsByYear W20614300642019 @default.
• W2061430064 countsByYear W20614300642020 @default.
• W2061430064 countsByYear W20614300642021 @default.
• W2061430064 countsByYear W20614300642022 @default.
• W2061430064 countsByYear W20614300642023 @default.
• W2061430064 crossrefType "journal-article" @default.
• W2061430064 hasAuthorship W2061430064A5002590827 @default.
• W2061430064 hasAuthorship W2061430064A5015432344 @default.
• W2061430064 hasAuthorship W2061430064A5020931362 @default.
• W2061430064 hasAuthorship W2061430064A5043793009 @default.
• W2061430064 hasAuthorship W2061430064A5051570381 @default.
• W2061430064 hasAuthorship W2061430064A5083356558 @default.
• W2061430064 hasAuthorship W2061430064A5089820455 @default.
• W2061430064 hasAuthorship W2061430064A5090202478 @default.
• W2061430064 hasConcept C121608353 @default.
• W2061430064 hasConcept C126322002 @default.
• W2061430064 hasConcept C143998085 @default.
• W2061430064 hasConcept C146357865 @default.
• W2061430064 hasConcept C151730666 @default.
• W2061430064 hasConcept C156957248 @default.
• W2061430064 hasConcept C207103383 @default.
• W2061430064 hasConcept C2777154038 @default.
• W2061430064 hasConcept C2777546739 @default.
• W2061430064 hasConcept C2778740770 @default.
• W2061430064 hasConcept C2779013556 @default.
• W2061430064 hasConcept C2780849966 @default.
• W2061430064 hasConcept C44249647 @default.
• W2061430064 hasConcept C50382708 @default.
• W2061430064 hasConcept C526805850 @default.
• W2061430064 hasConcept C71924100 @default.
• W2061430064 hasConcept C86803240 @default.
• W2061430064 hasConcept C90924648 @default.
• W2061430064 hasConceptScore W2061430064C121608353 @default.
• W2061430064 hasConceptScore W2061430064C126322002 @default.
• W2061430064 hasConceptScore W2061430064C143998085 @default.
• W2061430064 hasConceptScore W2061430064C146357865 @default.
• W2061430064 hasConceptScore W2061430064C151730666 @default.
• W2061430064 hasConceptScore W2061430064C156957248 @default.
• W2061430064 hasConceptScore W2061430064C207103383 @default.
• W2061430064 hasConceptScore W2061430064C2777154038 @default.
• W2061430064 hasConceptScore W2061430064C2777546739 @default.

• next