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- W2061433416 abstract "Natural killer (NK) cells are key components of innate immune responses, providing surveillance against cells undergoing tumorigenesis or infection, by viruses or internal pathogens. NK cells can directly eliminate compromised cells and regulate downstream responses of the innate and acquired immune systems through the release of immune modulators (cytokines, interferons). The importance of the role NK cells play in immune defense was demonstrated originally in herpes viral infections, usually mild or localized, which become severe and life threatening in NK-deficient patients . NK cell effector functions are governed by balancing opposing signals from a diverse array of activating and inhibitory receptors. Many NK receptors occur in paired activating and inhibitory isoforms and recognize major histocompatibility complex (MHC) class I proteins with varying degrees of peptide specificity. Structural studies have made considerable inroads into understanding the molecular mechanisms employed to broadly recognize multiple MHC ligands or specific pathogen-associated antigens and the strategies employed by viruses to thwart these defenses. Although many details of NK development, signaling, and integration remain mysterious, it is clear that NK receptors are key components of a system exquisitely tuned to sense any dysregulation in MHC class I expression, or the expression of certain viral antigens, resulting in the elimination of affected cells." @default.
- W2061433416 created "2016-06-24" @default.
- W2061433416 creator A5030551505 @default.
- W2061433416 creator A5041953387 @default.
- W2061433416 date "2012-10-10" @default.
- W2061433416 modified "2023-10-16" @default.
- W2061433416 title "Structural insights into activation of antiviral NK cell responses" @default.
- W2061433416 cites W14494190 @default.
- W2061433416 cites W1484816825 @default.
- W2061433416 cites W1500247462 @default.
- W2061433416 cites W1506621673 @default.
- W2061433416 cites W1534791573 @default.
- W2061433416 cites W1541594543 @default.
- W2061433416 cites W1551056911 @default.
- W2061433416 cites W1576474563 @default.
- W2061433416 cites W1585977107 @default.
- W2061433416 cites W1605872885 @default.
- W2061433416 cites W161539441 @default.
- W2061433416 cites W1617050454 @default.
- W2061433416 cites W1620801087 @default.
- W2061433416 cites W1639242915 @default.
- W2061433416 cites W1890880588 @default.
- W2061433416 cites W1900016038 @default.
- W2061433416 cites W1906987668 @default.
- W2061433416 cites W1927002144 @default.
- W2061433416 cites W1933196798 @default.
- W2061433416 cites W1951252517 @default.
- W2061433416 cites W1963309870 @default.
- W2061433416 cites W1963813930 @default.
- W2061433416 cites W1965805920 @default.
- W2061433416 cites W1966280572 @default.
- W2061433416 cites W1967968626 @default.
- W2061433416 cites W1969814796 @default.
- W2061433416 cites W1971949547 @default.
- W2061433416 cites W1972282386 @default.
- W2061433416 cites W1974670739 @default.
- W2061433416 cites W1975440573 @default.
- W2061433416 cites W1977190777 @default.
- W2061433416 cites W1977339743 @default.
- W2061433416 cites W1979386953 @default.
- W2061433416 cites W1980036435 @default.
- W2061433416 cites W1981657600 @default.
- W2061433416 cites W1983622219 @default.
- W2061433416 cites W1984341857 @default.
- W2061433416 cites W1984377155 @default.
- W2061433416 cites W1987617614 @default.
- W2061433416 cites W1990659001 @default.
- W2061433416 cites W1992692237 @default.
- W2061433416 cites W1992849411 @default.
- W2061433416 cites W1993071851 @default.
- W2061433416 cites W1994347380 @default.
- W2061433416 cites W1994716838 @default.
- W2061433416 cites W1996891899 @default.
- W2061433416 cites W1997714286 @default.
- W2061433416 cites W1999839845 @default.
- W2061433416 cites W2000461732 @default.
- W2061433416 cites W2001372707 @default.
- W2061433416 cites W2003676228 @default.
- W2061433416 cites W2005561356 @default.
- W2061433416 cites W2005765588 @default.
- W2061433416 cites W2006239488 @default.
- W2061433416 cites W2006278700 @default.
- W2061433416 cites W2007542983 @default.
- W2061433416 cites W2008221423 @default.
- W2061433416 cites W2008296972 @default.
- W2061433416 cites W2008919922 @default.
- W2061433416 cites W2011265839 @default.
- W2061433416 cites W2013473454 @default.
- W2061433416 cites W2013684768 @default.
- W2061433416 cites W2014144836 @default.
- W2061433416 cites W2014208459 @default.
- W2061433416 cites W2020639004 @default.
- W2061433416 cites W2020846586 @default.
- W2061433416 cites W2021384146 @default.
- W2061433416 cites W2021668965 @default.
- W2061433416 cites W2022609860 @default.
- W2061433416 cites W2027315624 @default.
- W2061433416 cites W2027470770 @default.
- W2061433416 cites W2029993034 @default.
- W2061433416 cites W2031235649 @default.
- W2061433416 cites W2032404927 @default.
- W2061433416 cites W2034694119 @default.
- W2061433416 cites W2035225697 @default.
- W2061433416 cites W2035470798 @default.
- W2061433416 cites W2035494444 @default.
- W2061433416 cites W2035503835 @default.
- W2061433416 cites W2035860688 @default.
- W2061433416 cites W2036032819 @default.
- W2061433416 cites W2038029622 @default.
- W2061433416 cites W2038509173 @default.
- W2061433416 cites W2038712890 @default.
- W2061433416 cites W2039266996 @default.
- W2061433416 cites W2043152685 @default.
- W2061433416 cites W2044016143 @default.
- W2061433416 cites W2044342378 @default.
- W2061433416 cites W2046899427 @default.
- W2061433416 cites W2047398809 @default.
- W2061433416 cites W2048804569 @default.