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- W2061449590 abstract "Eight patients undergoing antidepressant therapy with nortriptyline for 1--4 years were investigated. The period of the investigation was 7 weeks and included a 2-week placebo period, blind for the patients. Total saliva secretion measurement, the nortriptyline plasma level, and signs and symptoms of depression and side effects were obtained once a week during the study. The results of the investigation were: (1) long-term treatment with nortriptyline is followed by hyposecretion or xerostomia, (2) the reduction of the secretion is reversible, (3) re-establishment of treatment with dosage leading to the same serum level of nortriptyline is immediately followed by a drop in saliva secretion, and (4) the changes in salivary secretion are useful as an indicator of side effects. The practical importance of the investigation is discussed." @default.
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- W2061449590 date "1979-02-01" @default.
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- W2061449590 title "Saliva secretion following long-term antidepressant treatment with nortriptyline controlled by plasma levels" @default.
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- W2061449590 doi "https://doi.org/10.1111/j.1600-0722.1979.tb01940.x" @default.
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