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• W2061449969 abstract "We tested the hypothesis that changes in endogenous neuroactive steroids acting as positive allosteric modulators of γ–aminobutyric acid (GABA)A receptors may be related to the menopause-associated mood alterations. The study sample consisted of twenty five drug-free menopausal women, 1–3 years since the onset of menopause, homogeneous for age and body mass index (BMI) and without personal history of psychiatric, metabolic or endocrine disorders. Depression and anxiety-related symptoms were assessed with the Zung Self-administered Depression Scale (ZSDS) and the Cornell's Dysthymia Rating Scale (CDRS). The cut-off value predicted by the ZSDS index defined two groups of women (asymptomatic [35.5±4.6, n=12] and symptomatic [60.8±7.9, n=13]), that were also significantly different according to the CDRS scores (10.6±3.4 and 31.5±12, respectively, P<0.05). Upon evaluation of the scores relative to the anxiety factor of the CDRS (items 11–15) the symptomatic, but not the asymptomatic, group showed a moderate level of anxiety. The plasma concentrations of several neuroactive steroids were measured, after extraction and HPLC purification, by radioimmunoassay with specific antisera. Only dehydroepiandrosterone and its metabolite 5α–androstane–3α,17βdiol (3α–ADIOL), a positive allosteric modulator of GABAA receptors, were significantly (P<0.05 and P<0.005) higher (+110% and +64%, respectively) in the asymptomatic group. A highly significant and negative correlation (r=−0.672, P=0.003) was found between the plasma 3α–ADIOL concentrations and the scores of the anxiety factor of the CDRS. These data suggest that endogenous 3α–ADIOL modulates the central GABAergic tone and that higher 3α–ADIOL concentrations could have a role in preventing the expression of anxiety in the asymptomatic women." @default.
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• W2061449969 date "2000-10-01" @default.
• W2061449969 modified "2023-09-25" @default.
• W2061449969 title "Plasma 5α–androstane–3α,17βdiol, an endogenous steroid that positively modulates GABAA receptor function, and anxiety: a study in menopausal women" @default.
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• W2061449969 doi "https://doi.org/10.1016/s0306-4530(00)00017-2" @default.
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