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- W2061464562 abstract "The taste of four fluoro substituted derivatives (2a, 2b, 2c and 2d) is almost indistinguishable from that of the parent compound 4-(4-hydroxyphenyl)butan-2-one (1), the main flavor component of raspberries. The same holds for the comparison between the corresponding acetate, another raspberry ingredient, and its 1-fluoro analogue (2e). In contrast, methyl substituents (as present in compounds 3a, 3b, 3c, 3d and 3e) profoundly alter the organoleptic properties. - The preparation of the fluorinated derivatives (2) involved the three principal options existing for the incorporation of fluorine into organic molecular skeletons: the use of “prefabricates” (i.e., of fluoroaromatic building blocks), the formation of chlorofluorocarbene cycloadducts followed by their solvolytic ring opening and the addition of fluoride to olefinic double bonds." @default.
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- W2061464562 date "1996-01-01" @default.
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- W2061464562 title "About the “physiological size” of fluorine substituents: Comparison of sensorially active compounds with fluorine and methyl substituted analogues" @default.
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- W2061464562 doi "https://doi.org/10.1016/0040-4020(95)00886-d" @default.
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