FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061467047> ?p ?o ?g. }

• W2061467047 endingPage "4036" @default.
• W2061467047 startingPage "4031" @default.
• W2061467047 abstract "Background: The negative signaling provided by interactions of the co-inhibitory molecule, programmed death-1 (PD-1), and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), is a critical mechanism contributing to tumor evasion; blockade of this pathway has been proven to enhance cytotoxic activity and mediate antitumor therapy. Here we evaluated the anti-tumor efficacy of AAV-mediated delivery of the extracellular domain of murine PD-1 (sPD-1) to a tumor site. Material and Methods: An rAAV vector was constructed in which the expression of sPD-1, a known negative regulator of TCR signals, is driven by human cytomegalovirus immediate early promoter (CMV-P), using a triple plasmid transfection system. Tumor-bearing mice were then treated with the AAV/sPD1 construct and expression of sPD-1 in tumor tissues was determined by semi quantitative RT-PCR, and tumor weights and cytotoxic activity of splenocytes were measured. Results: Analysis of tumor homogenates revealed sPD-1 mRNA to be significantly overexpressed in rAAV/sPD-1 treated mice as compared with control levels. Its use for local gene therapy at the inoculation site of H22 hepatoma cells could inhibit tumor growth, also enhancing lysis of tumor cells by lymphocytes stimulated specifically with an antigen. In addition, PD-1 was also found expressed on the surfaces of activated CD8+ T cells. Conclusion: This study confirmed that expression of the soluble extracellular domain of PD-1 molecule could reduce tumor microenvironment inhibitory effects on T cells and enhance cytotoxicity. This suggests that it might be a potential target for development of therapies to augment T-cell responses in patients with malignancies." @default.
• W2061467047 created "2016-06-24" @default.
• W2061467047 creator A5000163853 @default.
• W2061467047 creator A5011875487 @default.
• W2061467047 creator A5016677423 @default.
• W2061467047 creator A5039909130 @default.
• W2061467047 creator A5048936740 @default.
• W2061467047 creator A5078016930 @default.
• W2061467047 creator A5080222187 @default.
• W2061467047 creator A5087446131 @default.
• W2061467047 creator A5090603992 @default.
• W2061467047 date "2012-08-31" @default.
• W2061467047 modified "2023-09-27" @default.
• W2061467047 title "Reconstructed Adeno-Associated Virus with the Extracellular Domain of Murine PD-1 Induces Antitumor Immunity" @default.
• W2061467047 cites W1498311899 @default.
• W2061467047 cites W1568276869 @default.
• W2061467047 cites W1577612079 @default.
• W2061467047 cites W1870078228 @default.
• W2061467047 cites W1907001600 @default.
• W2061467047 cites W1975867402 @default.
• W2061467047 cites W1990156180 @default.
• W2061467047 cites W2005393061 @default.
• W2061467047 cites W2016983859 @default.
• W2061467047 cites W2018271388 @default.
• W2061467047 cites W2023061657 @default.
• W2061467047 cites W2025953787 @default.
• W2061467047 cites W2029141733 @default.
• W2061467047 cites W2056943423 @default.
• W2061467047 cites W2073382063 @default.
• W2061467047 cites W2082927803 @default.
• W2061467047 cites W2101204896 @default.
• W2061467047 cites W2106415083 @default.
• W2061467047 cites W2107556275 @default.
• W2061467047 cites W2111217091 @default.
• W2061467047 cites W2118471749 @default.
• W2061467047 cites W2125988127 @default.
• W2061467047 cites W2129806226 @default.
• W2061467047 cites W2134638467 @default.
• W2061467047 cites W2138062457 @default.
• W2061467047 cites W2166478326 @default.
• W2061467047 cites W2167284803 @default.
• W2061467047 cites W2169507300 @default.
• W2061467047 cites W2349220433 @default.
• W2061467047 doi "https://doi.org/10.7314/apjcp.2012.13.8.4031" @default.
• W2061467047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23098512" @default.
• W2061467047 hasPublicationYear "2012" @default.
• W2061467047 type Work @default.
• W2061467047 sameAs 2061467047 @default.
• W2061467047 citedByCount "47" @default.
• W2061467047 countsByYear W20614670472014 @default.
• W2061467047 countsByYear W20614670472015 @default.
• W2061467047 countsByYear W20614670472016 @default.
• W2061467047 countsByYear W20614670472017 @default.
• W2061467047 countsByYear W20614670472018 @default.
• W2061467047 countsByYear W20614670472019 @default.
• W2061467047 countsByYear W20614670472020 @default.
• W2061467047 countsByYear W20614670472021 @default.
• W2061467047 countsByYear W20614670472022 @default.
• W2061467047 countsByYear W20614670472023 @default.
• W2061467047 crossrefType "journal-article" @default.
• W2061467047 hasAuthorship W2061467047A5000163853 @default.
• W2061467047 hasAuthorship W2061467047A5011875487 @default.
• W2061467047 hasAuthorship W2061467047A5016677423 @default.
• W2061467047 hasAuthorship W2061467047A5039909130 @default.
• W2061467047 hasAuthorship W2061467047A5048936740 @default.
• W2061467047 hasAuthorship W2061467047A5078016930 @default.
• W2061467047 hasAuthorship W2061467047A5080222187 @default.
• W2061467047 hasAuthorship W2061467047A5087446131 @default.
• W2061467047 hasAuthorship W2061467047A5090603992 @default.
• W2061467047 hasBestOaLocation W20614670471 @default.
• W2061467047 hasConcept C104317684 @default.
• W2061467047 hasConcept C109316439 @default.
• W2061467047 hasConcept C111599444 @default.
• W2061467047 hasConcept C153911025 @default.
• W2061467047 hasConcept C154317977 @default.
• W2061467047 hasConcept C167672396 @default.
• W2061467047 hasConcept C185592680 @default.
• W2061467047 hasConcept C189976730 @default.
• W2061467047 hasConcept C202751555 @default.
• W2061467047 hasConcept C203014093 @default.
• W2061467047 hasConcept C2776107976 @default.
• W2061467047 hasConcept C28406088 @default.
• W2061467047 hasConcept C502942594 @default.
• W2061467047 hasConcept C54009773 @default.
• W2061467047 hasConcept C55493867 @default.
• W2061467047 hasConcept C86803240 @default.
• W2061467047 hasConcept C8891405 @default.
• W2061467047 hasConcept C95444343 @default.
• W2061467047 hasConceptScore W2061467047C104317684 @default.
• W2061467047 hasConceptScore W2061467047C109316439 @default.
• W2061467047 hasConceptScore W2061467047C111599444 @default.
• W2061467047 hasConceptScore W2061467047C153911025 @default.
• W2061467047 hasConceptScore W2061467047C154317977 @default.
• W2061467047 hasConceptScore W2061467047C167672396 @default.
• W2061467047 hasConceptScore W2061467047C185592680 @default.
• W2061467047 hasConceptScore W2061467047C189976730 @default.
• W2061467047 hasConceptScore W2061467047C202751555 @default.
• W2061467047 hasConceptScore W2061467047C203014093 @default.

• next