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- W206148601 abstract "Proanthocyanidins are oligomers and polymers of flavan-3-ols that are amongst the most abundant and bioactive polyphenols in the human diet. IPEC-1 cells are a non-transformed, non-tumorigenic cell line derived from pig ileum commonly used as a model to evaluate intestinal epithelial cell activity in vitro. In the present work, IPEC-1 cells were used to determine the effect of proanthocyanidins on immune and inflammatory gene expression. Cells were treated with highly purified proanthocyandin extracts from cranberry and grape seed under non-stimulated and LPS-stimulated conditions during a 48 h total incubation period at 37°C. Inflammatory gene expression levels for ICAM-1, CCL28, IL-8, TLR4, TNF-α, IL-25, IL-6, CCL20, MUC-2, IL12p40, CCL2 (MCP-1), and PTGS2 (COX-2) were analyzed by real-time RTPCR, and IL-8 protein production in cell supernatants was determined by ELISA. Our results showed no significant change in cell viability or apoptosis, but ICAM-1, CCL20, and IL-8 gene expression was up-regulated in response to proanthocyanidin extracts. Increased protein levels of IL-8 were consistent with increased gene expression. Our results suggested that proanthocyanidins stimulate components of the inflammatory response of IPEC-1 cells. This effect might be beneficial for certain immune-related diseases. Funded by the Spanish MICINN (AGL2010-17499) and ARS #1235-51530-053." @default.
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- W206148601 date "2012-04-01" @default.
- W206148601 modified "2023-09-26" @default.
- W206148601 title "Proanthocyanidins stimulate an inflammatory response in a pig intestinal epithelial cell line (IPEC‐1 cells)" @default.
- W206148601 doi "https://doi.org/10.1096/fasebj.26.1_supplement.644.7" @default.
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