FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061492982> ?p ?o ?g. }

• W2061492982 endingPage "R439" @default.
• W2061492982 startingPage "R432" @default.
• W2061492982 abstract "The expression of myocardial heat shock protein 72 (HSP72) postexercise is initiated by the activation of heat shock transcription factor 1 (HSF1). However, it remains unknown which physiological stimuli govern myocardial HSF1 activation during exercise. These experiments tested the hypothesis that thermal stress and mechanical load, concomitant with simulated exercise, provide independent stimuli for HSF1 activation and ensuing cardiac HSP72 gene expression. To elucidate the independent roles of increased temperature and cardiac workload in the exercise-mediated upregulation of left-ventricular HSP72, hearts from adult male Sprague-Dawley rats were randomly assigned to one of five simulated exercise conditions. Upon reaching a surgical plane of anesthesia, each experimental heart was isolated and perfused using an in vitro working heart model, while independently varying temperatures (i.e., 37°C vs. 40°C) and cardiac workloads (i.e., low preload and afterload vs. high preload and afterload) to mimic exercise responses. Results indicate that hyperthermia, independent of cardiac workload, promoted an increase in nuclear translocation and phosphorylation of HSF1 compared with normothermic left ventricles. Similarly, hyperthermia, independent of workload, resulted in significant increases in cardiac levels of HSP72 mRNA. Collectively, these data suggest that HSF1 activation and HSP72 gene transcriptional competence during simulated exercise are linked to elevated heart temperature and are not a direct function of increased cardiac workload." @default.
• W2061492982 created "2016-06-24" @default.
• W2061492982 creator A5025095995 @default.
• W2061492982 creator A5033152847 @default.
• W2061492982 creator A5048790008 @default.
• W2061492982 creator A5077382358 @default.
• W2061492982 creator A5079214111 @default.
• W2061492982 date "2007-01-01" @default.
• W2061492982 modified "2023-09-30" @default.
• W2061492982 title "Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart" @default.
• W2061492982 cites W1864857740 @default.
• W2061492982 cites W1881688083 @default.
• W2061492982 cites W1964301211 @default.
• W2061492982 cites W1967138582 @default.
• W2061492982 cites W1978489370 @default.
• W2061492982 cites W1984517822 @default.
• W2061492982 cites W1985034089 @default.
• W2061492982 cites W1985085579 @default.
• W2061492982 cites W1985565611 @default.
• W2061492982 cites W1987493586 @default.
• W2061492982 cites W1995486984 @default.
• W2061492982 cites W2003746499 @default.
• W2061492982 cites W2014027548 @default.
• W2061492982 cites W2015640955 @default.
• W2061492982 cites W2021269781 @default.
• W2061492982 cites W2023746083 @default.
• W2061492982 cites W2028761750 @default.
• W2061492982 cites W2029128612 @default.
• W2061492982 cites W2031493318 @default.
• W2061492982 cites W2035024999 @default.
• W2061492982 cites W2040160413 @default.
• W2061492982 cites W2051180448 @default.
• W2061492982 cites W2051793369 @default.
• W2061492982 cites W2053038596 @default.
• W2061492982 cites W2053151773 @default.
• W2061492982 cites W2056924571 @default.
• W2061492982 cites W2074632760 @default.
• W2061492982 cites W2075341017 @default.
• W2061492982 cites W2095397643 @default.
• W2061492982 cites W2104699504 @default.
• W2061492982 cites W2105895998 @default.
• W2061492982 cites W2108201412 @default.
• W2061492982 cites W2119624960 @default.
• W2061492982 cites W2122966855 @default.
• W2061492982 cites W2125134379 @default.
• W2061492982 cites W2136646013 @default.
• W2061492982 cites W2137417707 @default.
• W2061492982 cites W2137770738 @default.
• W2061492982 cites W2142157062 @default.
• W2061492982 cites W2145760315 @default.
• W2061492982 cites W2162500295 @default.
• W2061492982 cites W2180121032 @default.
• W2061492982 cites W2257751750 @default.
• W2061492982 cites W2288839112 @default.
• W2061492982 cites W2329810638 @default.
• W2061492982 cites W2468654678 @default.
• W2061492982 cites W4293247451 @default.
• W2061492982 doi "https://doi.org/10.1152/ajpregu.00895.2005" @default.
• W2061492982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16990482" @default.
• W2061492982 hasPublicationYear "2007" @default.
• W2061492982 type Work @default.
• W2061492982 sameAs 2061492982 @default.
• W2061492982 citedByCount "73" @default.
• W2061492982 countsByYear W20614929822012 @default.
• W2061492982 countsByYear W20614929822013 @default.
• W2061492982 countsByYear W20614929822014 @default.
• W2061492982 countsByYear W20614929822015 @default.
• W2061492982 countsByYear W20614929822016 @default.
• W2061492982 countsByYear W20614929822017 @default.
• W2061492982 countsByYear W20614929822018 @default.
• W2061492982 countsByYear W20614929822019 @default.
• W2061492982 countsByYear W20614929822020 @default.
• W2061492982 countsByYear W20614929822021 @default.
• W2061492982 countsByYear W20614929822022 @default.
• W2061492982 countsByYear W20614929822023 @default.
• W2061492982 crossrefType "journal-article" @default.
• W2061492982 hasAuthorship W2061492982A5025095995 @default.
• W2061492982 hasAuthorship W2061492982A5033152847 @default.
• W2061492982 hasAuthorship W2061492982A5048790008 @default.
• W2061492982 hasAuthorship W2061492982A5077382358 @default.
• W2061492982 hasAuthorship W2061492982A5079214111 @default.
• W2061492982 hasConcept C104317684 @default.
• W2061492982 hasConcept C111566952 @default.
• W2061492982 hasConcept C123576724 @default.
• W2061492982 hasConcept C126322002 @default.
• W2061492982 hasConcept C134018914 @default.
• W2061492982 hasConcept C164705383 @default.
• W2061492982 hasConcept C178853913 @default.
• W2061492982 hasConcept C185592680 @default.
• W2061492982 hasConcept C205260736 @default.
• W2061492982 hasConcept C2776667301 @default.
• W2061492982 hasConcept C2778198053 @default.
• W2061492982 hasConcept C2778921608 @default.
• W2061492982 hasConcept C2779949491 @default.
• W2061492982 hasConcept C48277249 @default.
• W2061492982 hasConcept C52981337 @default.
• W2061492982 hasConcept C55493867 @default.
• W2061492982 hasConcept C68991219 @default.

• next