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• W2061499765 abstract "Neuronal Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) interacts with several prominent dendritic spine proteins, which have been termed CaMKII-associated proteins. The NR2B subunit of <i>N</i>-methyl-d-aspartate (NMDA)-type glutamate receptor, densin-180, and α-actinin bind comparable, approximately stoichiometric amounts of Thr²⁸⁶-autophosphorylated CaMKIIα, forming a ternary complex (Robison, A. J., Bass, M. A., Jiao, Y., Macmillan, L. B., Carmody, L. C., Bartlett, R. K., and Colbran, R. J. (2005) <i>J. Biol. Chem.</i> 280, 35329-35336), but their impacts on CaMKII function are poorly understood. Here we show that these interactions are differentially regulated and exert distinct effects on CaMKII activity. Nonphosphorylated and Thr²⁸⁶-autophosphorylated CaMKII bind to α-actinin with similar efficacy, but autophosphorylation at Thr^305/306 or Ca²⁺/calmodulin binding significantly reduce this binding. Moreover, α-actinin antagonizes CaMKII activation by Ca²⁺/calmodulin, as assessed by autophosphorylation and phosphorylation of a peptide substrate. CaMKII binding to densin (1247-1542) is partially independent of Thr²⁸⁶ autophosphorylation and is unaffected by Ca²⁺-independent autophosphorylation or Ca²⁺/calmodulin. In addition, the CaMKII binding domain of densin-180 has little effect on CaMKII activity. In contrast, the interaction of CaMKIIα with NR2B requires either Thr²⁸⁶ autophosphorylation or the binding of both Ca²⁺/calmodulin and adenine nucleotides. NR2B inhibits both the Ca²⁺/calmodulin-dependent and autonomous activities of CaMKII by a mechanism that is competitive with autocamtide-2 substrate, non-competitive with syntide-2 substrate, and uncompetitive with respect to ATP. In combination, these data suggest that dynamically regulated interactions with CaMKII-associated proteins could play pleiotropic roles in finetuning CaMKII signaling in defined subcellular compartments." @default.
• W2061499765 created "2016-06-24" @default.
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• W2061499765 date "2005-11-01" @default.
• W2061499765 modified "2023-10-13" @default.
• W2061499765 title "Differential Modulation of Ca2+/Calmodulin-dependent Protein Kinase II Activity by Regulated Interactions with N-Methyl-D-aspartate Receptor NR2B Subunits and α-Actinin" @default.
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• W2061499765 doi "https://doi.org/10.1074/jbc.m508189200" @default.
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