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• W2061507241 abstract "Thirty-two patients with polymyositis were categorised into 4 groups: (1) 9pure9 polymyositis, (2) dermatomyositis, (3) myositis associated with autoimmune 9overlap syndrome9, and (4) those with associated malignancy. Serum from each patient was examined for a range of antinuclear antibodies. Seventeen patients had ANA detected by immunofluorescence, 18 patients had raised DNA binding (greater than 25 U/ml), of whom eight had levels greater than 50 U/ml (SI conversion: U/l = U/ml x 10(3)). Antibodies to soluble nuclear antigens were detected in 23 (72%) by 1 or more of 3 methods, and in all of these anti-RNP was the main antibody detected. Antibodies to other soluble antigens were also present in 6 sera. In 2 cases, both patients with SLE/myositis overlap, these were shown to be anti-Sm. The remaining 4 had antibodies to various protein components of the extracts, but it was not possible to demonstrate an antibody of diagnostic specificity for polymyositis. Furthermore, quantitation of anti-RNP and anti-DNA antibodies failed to define a distinct clinical entity or exclude malignant disease. High levels of anti-RNP antibodies showed an association with Raynaud9s phenomenon, sclerodactyly, and pulmonary fibrosis and an inverse correlation with the rash of dermatomyositis, suggesting that this antibody may be of pathogenetic rather than diagnostic significance." @default.
• W2061507241 created "2016-06-24" @default.
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• W2061507241 date "1997-08-01" @default.
• W2061507241 modified "2023-09-27" @default.
• W2061507241 title "Exposure and mineralogical correlates of pulmonary fibrosis in chrysotile asbestos workers." @default.
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• W2061507241 doi "https://doi.org/10.1136/oem.54.8.549" @default.
• W2061507241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1128979" @default.
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