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- W2061552627 abstract "Fumonisin B1 (FB1) is the most abundant of a series of sphingosine‐analog mycotoxins produced by Fusarium verticillioides, the major fungal contaminant of stored corn (maize) world‐wide. Fumonisins were originally isolated as environmental tumor promoters, and they remain a concern because they are frequent contaminants of corn‐derived food products intended for direct human consumption. FB1 inhibits ceramide synthase, which may account for its acute toxic effects, but understanding of its tumor promotion mechanism has been limited by the general lack of understanding in the field. There is no evidence for functional metabolism of fumonisins in mammals, but abiogenic conversions during food processing are a concern because some known conversion products retain biological activity, including hydrolyzed FB1 (HFB1). HFB1, formed by alkaline removal of FB1 side chains, is a frequent contaminant of lime‐treated corn products such as tortillas and tortilla chips. Humpf et al. (J. Biol. Chem., 273, 19060, 1998) ..." @default.
- W2061552627 created "2016-06-24" @default.
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- W2061552627 date "2004-01-01" @default.
- W2061552627 modified "2023-09-27" @default.
- W2061552627 title "N‐Fatty Acylation of Hydrolyzed Fumonisin B<sub>1</sub>, But Not of Intact Fumonisin B<sub>1</sub>, Strongly Enhances In Vitro Mammalian Toxicity" @default.
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- W2061552627 doi "https://doi.org/10.1081/txr-120030651" @default.
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