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• W2061554691 abstract "The choice of a suitable detergent-based membrane mimetic is of crucial importance for high-resolution NMR studies of membrane proteins. The present report describes a new approach of detergent screening. It is based on the comparison of 2D 1H,15N-correlation spectra of a protein in a membrane-bilayer “reference” medium and in “trial” detergent-based environments. The proposed “reference” medium is the lipid−protein nanodisc (LPN) representing nanoscale phospholipid bilayers wrapped around by apolipoprotein A-1. The set of zwitterionic (DPC, DMPC/DHPC), anionic (SDS, LMPG, LPPG), and weakly cationic (LDAO) detergent-based media was screened for their ability to represent the native structure of the isolated voltage-sensing domain (VSD) of the archaeal potassium channel KvAP. The VSD/LPN complexes composed of saturated zwitterionic (DMPC), anionic (DMPG), or a mixture of unsaturated differently charged (POPC/DOPG, 3:1) lipids were used as reference. All assayed detergent media demonstrate similar CD spectra of the domain with a high level (∼60%) of overall helicity but different 2D NMR spectra. Using the reference spectrum of the VSD in LPN, we were able to choose the detergent composition in which the membrane-like structure of the VSD is preserved." @default.
• W2061554691 created "2016-06-24" @default.
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• W2061554691 date "2010-04-01" @default.
• W2061554691 modified "2023-10-15" @default.
• W2061554691 title "Lipid−Protein Nanodiscs as Reference Medium in Detergent Screening for High-Resolution NMR Studies of Integral Membrane Proteins" @default.
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• W2061554691 doi "https://doi.org/10.1021/ja9097498" @default.
• W2061554691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20356311" @default.
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