FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061567234> ?p ?o ?g. }

• W2061567234 abstract "The established correlation between neurodegenerative disorders and intracerebral deposition of polyglutamine aggregates motivates attempts to better understand their fibrillar structure. We designed polyglutamines with a few lysines inserted to overcome the hindrance of extreme insolubility and two D-lysines to limit the lengths of β-strands. One is 33 amino acids long (PolyQKd-33) and the other has one fewer glutamine (PolyQKd-32). Both form well-dispersed fibrils suitable for analysis by electron microscopy. Electron diffraction confirmed cross-β structures in both fibrils. Remarkably, the deletion of just one glutamine residue from the middle of the peptide leads to substantially different amyloid structures. PolyQKd-32 fibrils are consistently 10-20% wider than PolyQKd-33, as measured by negative staining, cryo-electron microscopy, and scanning transmission electron microscopy. Scanning transmission electron microscopy analysis revealed that the PolyQKd-32 fibrils have 50% higher mass-per-length than PolyQKd-33. This distinction can be explained by a superpleated β-structure model for PolyQKd-33 and a model with two β-solenoid protofibrils for PolyQKd-32. These data provide evidence for β-arch-containing structures in polyglutamine fibrils and open future possibilities for structure-based drug design." @default.
• W2061567234 created "2016-06-24" @default.
• W2061567234 creator A5001710213 @default.
• W2061567234 creator A5005541485 @default.
• W2061567234 creator A5027832312 @default.
• W2061567234 creator A5038633563 @default.
• W2061567234 creator A5048846433 @default.
• W2061567234 creator A5062504169 @default.
• W2061567234 creator A5063494245 @default.
• W2061567234 creator A5066358175 @default.
• W2061567234 creator A5090643634 @default.
• W2061567234 date "2014-05-01" @default.
• W2061567234 modified "2023-10-14" @default.
• W2061567234 title "Conformational Switching in PolyGln Amyloid Fibrils Resulting from a Single Amino Acid Insertion" @default.
• W2061567234 cites W133512539 @default.
• W2061567234 cites W1504256340 @default.
• W2061567234 cites W1544926311 @default.
• W2061567234 cites W1561055557 @default.
• W2061567234 cites W1675353672 @default.
• W2061567234 cites W1966457778 @default.
• W2061567234 cites W1978672495 @default.
• W2061567234 cites W1981396716 @default.
• W2061567234 cites W1986191025 @default.
• W2061567234 cites W1986769472 @default.
• W2061567234 cites W1990383225 @default.
• W2061567234 cites W1996667889 @default.
• W2061567234 cites W1996789718 @default.
• W2061567234 cites W1996810321 @default.
• W2061567234 cites W1998494120 @default.
• W2061567234 cites W2008307658 @default.
• W2061567234 cites W2014887526 @default.
• W2061567234 cites W2026332191 @default.
• W2061567234 cites W2032146255 @default.
• W2061567234 cites W2032255653 @default.
• W2061567234 cites W2034160988 @default.
• W2061567234 cites W2042716629 @default.
• W2061567234 cites W2055035610 @default.
• W2061567234 cites W2061279823 @default.
• W2061567234 cites W2069433780 @default.
• W2061567234 cites W2072613948 @default.
• W2061567234 cites W2074007203 @default.
• W2061567234 cites W2075813074 @default.
• W2061567234 cites W2079250951 @default.
• W2061567234 cites W2079902305 @default.
• W2061567234 cites W2081595285 @default.
• W2061567234 cites W2088661320 @default.
• W2061567234 cites W2092711025 @default.
• W2061567234 cites W2101747555 @default.
• W2061567234 cites W2103298870 @default.
• W2061567234 cites W2108570063 @default.
• W2061567234 cites W2114914350 @default.
• W2061567234 cites W2123544060 @default.
• W2061567234 cites W2126719129 @default.
• W2061567234 cites W2147282851 @default.
• W2061567234 cites W2165102205 @default.
• W2061567234 doi "https://doi.org/10.1016/j.bpj.2014.03.047" @default.
• W2061567234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4052364" @default.
• W2061567234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24853742" @default.
• W2061567234 hasPublicationYear "2014" @default.
• W2061567234 type Work @default.
• W2061567234 sameAs 2061567234 @default.
• W2061567234 citedByCount "3" @default.
• W2061567234 countsByYear W20615672342015 @default.
• W2061567234 countsByYear W20615672342016 @default.
• W2061567234 countsByYear W20615672342018 @default.
• W2061567234 crossrefType "journal-article" @default.
• W2061567234 hasAuthorship W2061567234A5001710213 @default.
• W2061567234 hasAuthorship W2061567234A5005541485 @default.
• W2061567234 hasAuthorship W2061567234A5027832312 @default.
• W2061567234 hasAuthorship W2061567234A5038633563 @default.
• W2061567234 hasAuthorship W2061567234A5048846433 @default.
• W2061567234 hasAuthorship W2061567234A5062504169 @default.
• W2061567234 hasAuthorship W2061567234A5063494245 @default.
• W2061567234 hasAuthorship W2061567234A5066358175 @default.
• W2061567234 hasAuthorship W2061567234A5090643634 @default.
• W2061567234 hasBestOaLocation W20615672341 @default.
• W2061567234 hasConcept C120665830 @default.
• W2061567234 hasConcept C121332964 @default.
• W2061567234 hasConcept C12554922 @default.
• W2061567234 hasConcept C146088050 @default.
• W2061567234 hasConcept C159985019 @default.
• W2061567234 hasConcept C166029249 @default.
• W2061567234 hasConcept C171250308 @default.
• W2061567234 hasConcept C179104552 @default.
• W2061567234 hasConcept C185592680 @default.
• W2061567234 hasConcept C192562407 @default.
• W2061567234 hasConcept C26771246 @default.
• W2061567234 hasConcept C27523624 @default.
• W2061567234 hasConcept C2777633098 @default.
• W2061567234 hasConcept C2779281246 @default.
• W2061567234 hasConcept C2779349466 @default.
• W2061567234 hasConcept C2781338088 @default.
• W2061567234 hasConcept C515207424 @default.
• W2061567234 hasConcept C55493867 @default.
• W2061567234 hasConcept C8010536 @default.
• W2061567234 hasConcept C86803240 @default.
• W2061567234 hasConcept C93877712 @default.
• W2061567234 hasConceptScore W2061567234C120665830 @default.
• W2061567234 hasConceptScore W2061567234C121332964 @default.
• W2061567234 hasConceptScore W2061567234C12554922 @default.

• next