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- W2061569046 abstract "Background: Intrauterine infection with Ureaplasmaspp is associated with an increased risk for the development of chronic lungdisease in preterm infants. The aim of the present study was to determine the effect of postnatal clarithromycin on the development of chronic lung diseasein preterm infants with isolation of Ureaplasma spp. within the amniotic cavityat birth. Patientsand Methods: Amniotic cavity cultures were performed prospectively in preterm deliveries<34 weeks GA and analyzed for presence of Ureaplasma spp. at the Departments of Obstetrics and Gynecology and Neonatology of the University Hospital Vienna. One-hundred and twelve patients positive for Ureaplasma spp within the amniotic cavity were included into the study during 11/2002 to 10/2005. Fifty-five patients were randomised to receive clarithromycin for 10to 14 days, 57 patients were randomised to the control group. Results: Gestational age and birthweight were significantly higher in the control group: median (min-max) 29 (24–33) vs. 27 (24–32) weeks, p=0.0007; 1257 (510–1915) vs. 1020 (500–1967)g, p=0.0005. Mortality was 14,5% in the treatment arm and 12,3% in the control arm. Chroniclung disease, defined as oxygen at 36 weeks gestational age, was diagnosed in 9,1% of patients in the treatment group and 17,5% in the control group. CLD ordeath at 36 weeks gestational age was diagnosed in 23,6% of the treatment patients and 26,3% of control patients. CLD in patients who survived until 36weeks of GA was 10,6% in treatment and 19,2% in control patients, respectively. Conclusion: Although there was a trend towardsreduced diagnosis of CLD at the age of 36 weeks after treatment with clarithromycin for 10 to 14 days after births as opposed to control patients, we were not able to show a statistically significant difference. However, gestational age and birthweight were distributed unequally in treatment and control groups with significantly lower median gestational age and birthweight in the treatment group." @default.
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- W2061569046 date "2007-01-01" @default.
- W2061569046 modified "2023-09-27" @default.
- W2061569046 title "Randomised trial on the use of clarithromycin for prevention of chronic lung disease in preterm infants with isolation of Ureaplasma species within the amniotic cavity at birth" @default.
- W2061569046 doi "https://doi.org/10.1055/s-2007-983085" @default.
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