FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061569444> ?p ?o ?g. }

• W2061569444 endingPage "1188" @default.
• W2061569444 startingPage "1180" @default.
• W2061569444 abstract "Cholecystokinin (CCK) is anorexic, irrespective whether it is applied intraperitoneally (IP) or intracerebroventricularly (ICV) in male Wistar rats. The metabolic effects depend on the route of administration: by the IP route it elicits hypothermia (presumably by type-1 receptors, CCK1R-s), while ICV administration is followed by fever-like hypermetabolism and hyperthermia via activation of CCK2R-s, which latter response seems to be most important in the postprandial (compensatory) hypermetabolism. The efficacy of the IP injected CCK varies with age: it causes strong anorexia in young adult 4 and 6-months old and again in old rats (aged 18–24 months), but the middle-aged (12-month old) ones seem to be resistant to this effect. Such pattern of effects may contribute to the explanation of age-related obesity observed in middle-aged animals as well as to the aging anorexia and loss of body weight in old ones. Diet-induced obesity accelerates the appearance of CCK-resistance as well as the return of high sensitivity to CCK in further aging, while chronic calorie-restriction prevents the development of resistance, as if the speed of the age-related regulatory changes was altered by the nutritional state. The effects of ICV applied CCK also change with age: the characteristic anorexic and hypermetabolic/hyperthermic effects can be observed in young adult rats, but the effects gradually and monotonically decline with age and disappear by the old age of 24 months. These disparate age-related patterns of CCK efficacy upon peripheral or central administration routes may indicate that although both peripheral and central CCKR-s exert anorexic effects, they may have dissimilar roles in the regulation of overall energy balance." @default.
• W2061569444 created "2016-06-24" @default.
• W2061569444 creator A5000164823 @default.
• W2061569444 creator A5001247650 @default.
• W2061569444 creator A5002696415 @default.
• W2061569444 creator A5030168256 @default.
• W2061569444 creator A5042457811 @default.
• W2061569444 creator A5047690213 @default.
• W2061569444 creator A5053937395 @default.
• W2061569444 creator A5070633235 @default.
• W2061569444 creator A5077596783 @default.
• W2061569444 creator A5083731246 @default.
• W2061569444 date "2013-11-01" @default.
• W2061569444 modified "2023-10-07" @default.
• W2061569444 title "Age and nutritional state influence the effects of cholecystokinin on energy balance" @default.
• W2061569444 cites W1566994573 @default.
• W2061569444 cites W1971672774 @default.
• W2061569444 cites W1972554285 @default.
• W2061569444 cites W1977163905 @default.
• W2061569444 cites W1978850139 @default.
• W2061569444 cites W1982248055 @default.
• W2061569444 cites W1982448464 @default.
• W2061569444 cites W1983092748 @default.
• W2061569444 cites W1984881189 @default.
• W2061569444 cites W1987089805 @default.
• W2061569444 cites W1987138596 @default.
• W2061569444 cites W1992893989 @default.
• W2061569444 cites W1993548967 @default.
• W2061569444 cites W1994091958 @default.
• W2061569444 cites W1999542628 @default.
• W2061569444 cites W2002140363 @default.
• W2061569444 cites W2005230188 @default.
• W2061569444 cites W2008136100 @default.
• W2061569444 cites W2011847859 @default.
• W2061569444 cites W2020998805 @default.
• W2061569444 cites W2021395359 @default.
• W2061569444 cites W2033423680 @default.
• W2061569444 cites W2041789901 @default.
• W2061569444 cites W2042209138 @default.
• W2061569444 cites W2062297990 @default.
• W2061569444 cites W2063662253 @default.
• W2061569444 cites W2065718106 @default.
• W2061569444 cites W2069601051 @default.
• W2061569444 cites W2069717883 @default.
• W2061569444 cites W2070267710 @default.
• W2061569444 cites W2070766330 @default.
• W2061569444 cites W2071723141 @default.
• W2061569444 cites W2071928653 @default.
• W2061569444 cites W2077515738 @default.
• W2061569444 cites W2079326719 @default.
• W2061569444 cites W2084004287 @default.
• W2061569444 cites W2084776830 @default.
• W2061569444 cites W2090386425 @default.
• W2061569444 cites W2090966517 @default.
• W2061569444 cites W2104390997 @default.
• W2061569444 cites W2113029268 @default.
• W2061569444 cites W2130643200 @default.
• W2061569444 cites W2135621257 @default.
• W2061569444 cites W6166819 @default.
• W2061569444 doi "https://doi.org/10.1016/j.exger.2013.07.006" @default.
• W2061569444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23876629" @default.
• W2061569444 hasPublicationYear "2013" @default.
• W2061569444 type Work @default.
• W2061569444 sameAs 2061569444 @default.
• W2061569444 citedByCount "17" @default.
• W2061569444 countsByYear W20615694442014 @default.
• W2061569444 countsByYear W20615694442015 @default.
• W2061569444 countsByYear W20615694442016 @default.
• W2061569444 countsByYear W20615694442017 @default.
• W2061569444 countsByYear W20615694442018 @default.
• W2061569444 countsByYear W20615694442019 @default.
• W2061569444 countsByYear W20615694442020 @default.
• W2061569444 countsByYear W20615694442022 @default.
• W2061569444 countsByYear W20615694442023 @default.
• W2061569444 crossrefType "journal-article" @default.
• W2061569444 hasAuthorship W2061569444A5000164823 @default.
• W2061569444 hasAuthorship W2061569444A5001247650 @default.
• W2061569444 hasAuthorship W2061569444A5002696415 @default.
• W2061569444 hasAuthorship W2061569444A5030168256 @default.
• W2061569444 hasAuthorship W2061569444A5042457811 @default.
• W2061569444 hasAuthorship W2061569444A5047690213 @default.
• W2061569444 hasAuthorship W2061569444A5053937395 @default.
• W2061569444 hasAuthorship W2061569444A5070633235 @default.
• W2061569444 hasAuthorship W2061569444A5077596783 @default.
• W2061569444 hasAuthorship W2061569444A5083731246 @default.
• W2061569444 hasBestOaLocation W20615694441 @default.
• W2061569444 hasConcept C126322002 @default.
• W2061569444 hasConcept C134018914 @default.
• W2061569444 hasConcept C151279926 @default.
• W2061569444 hasConcept C170493617 @default.
• W2061569444 hasConcept C2777390192 @default.
• W2061569444 hasConcept C2777464067 @default.
• W2061569444 hasConcept C2777593968 @default.
• W2061569444 hasConcept C2778199505 @default.
• W2061569444 hasConcept C2778654693 @default.
• W2061569444 hasConcept C2778707264 @default.
• W2061569444 hasConcept C2779306644 @default.
• W2061569444 hasConcept C42407357 @default.

• next