Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061569585> ?p ?o ?g. }
- W2061569585 endingPage "827" @default.
- W2061569585 startingPage "822" @default.
- W2061569585 abstract "Interferons (IFNs) have been investigated as important cytokines in immunotherapy. The use of IFNs in cancer immunotherapy has had limited success. In this study, IFN genes were delivered into B16 melanoma cells by lentiviral vectors, and their effects on B16 melanoma were comprehensively analyzed. Type II IFN significantly impaired the viability of B16 cells in vitro. Expression of IFNα and IFNβ in B16 cells efficiently suppressed the establishment of inoculated melanoma. However, intratumoral delivery of IFNs alone with lentiviral vectors had no therapeutic effects on established melanoma. To address the lack of response, a lentivector was constructed to simultaneously transfer therapeutic genes and small interfering RNAs (siRNAs). IFNs and siRNA targeting signal transducer and activator of transcription 3 (STAT3), which is a major immune suppressive transcription factor in melanoma, were delivered simultaneously into the tumor milieu. This treatment successfully rescued the response to IFNγ and attenuated the growth of established tumors. This method has the potential to improve the therapeutic effects of IFNs in cancer immunotherapy." @default.
- W2061569585 created "2016-06-24" @default.
- W2061569585 creator A5051640223 @default.
- W2061569585 creator A5058840032 @default.
- W2061569585 creator A5069327731 @default.
- W2061569585 creator A5074110801 @default.
- W2061569585 creator A5080956893 @default.
- W2061569585 creator A5081112807 @default.
- W2061569585 creator A5091378190 @default.
- W2061569585 date "2012-09-28" @default.
- W2061569585 modified "2023-10-06" @default.
- W2061569585 title "Delivery of interferons and siRNA targeting STAT3 using lentiviral vectors suppresses the growth of murine melanoma" @default.
- W2061569585 cites W1642873092 @default.
- W2061569585 cites W1960879525 @default.
- W2061569585 cites W1965881928 @default.
- W2061569585 cites W1966601696 @default.
- W2061569585 cites W1969061773 @default.
- W2061569585 cites W1982027307 @default.
- W2061569585 cites W1984700841 @default.
- W2061569585 cites W1991700501 @default.
- W2061569585 cites W1999468766 @default.
- W2061569585 cites W2004630197 @default.
- W2061569585 cites W2007897471 @default.
- W2061569585 cites W2010145861 @default.
- W2061569585 cites W2011937137 @default.
- W2061569585 cites W2013584598 @default.
- W2061569585 cites W2026318599 @default.
- W2061569585 cites W2031502153 @default.
- W2061569585 cites W2034640715 @default.
- W2061569585 cites W2037265356 @default.
- W2061569585 cites W2042794591 @default.
- W2061569585 cites W2047404721 @default.
- W2061569585 cites W2052313621 @default.
- W2061569585 cites W2055279578 @default.
- W2061569585 cites W2059038945 @default.
- W2061569585 cites W2076035862 @default.
- W2061569585 cites W2086770363 @default.
- W2061569585 cites W2099156986 @default.
- W2061569585 cites W2117692326 @default.
- W2061569585 cites W2136570726 @default.
- W2061569585 cites W2141570423 @default.
- W2061569585 cites W2144078346 @default.
- W2061569585 cites W2154024950 @default.
- W2061569585 cites W2168478794 @default.
- W2061569585 cites W2170090299 @default.
- W2061569585 cites W2170957438 @default.
- W2061569585 cites W2313311604 @default.
- W2061569585 cites W2783142245 @default.
- W2061569585 cites W4241607104 @default.
- W2061569585 cites W83138054 @default.
- W2061569585 doi "https://doi.org/10.1038/cgt.2012.65" @default.
- W2061569585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23018621" @default.
- W2061569585 hasPublicationYear "2012" @default.
- W2061569585 type Work @default.
- W2061569585 sameAs 2061569585 @default.
- W2061569585 citedByCount "8" @default.
- W2061569585 countsByYear W20615695852013 @default.
- W2061569585 countsByYear W20615695852015 @default.
- W2061569585 countsByYear W20615695852019 @default.
- W2061569585 countsByYear W20615695852022 @default.
- W2061569585 countsByYear W20615695852023 @default.
- W2061569585 crossrefType "journal-article" @default.
- W2061569585 hasAuthorship W2061569585A5051640223 @default.
- W2061569585 hasAuthorship W2061569585A5058840032 @default.
- W2061569585 hasAuthorship W2061569585A5069327731 @default.
- W2061569585 hasAuthorship W2061569585A5074110801 @default.
- W2061569585 hasAuthorship W2061569585A5080956893 @default.
- W2061569585 hasAuthorship W2061569585A5081112807 @default.
- W2061569585 hasAuthorship W2061569585A5091378190 @default.
- W2061569585 hasBestOaLocation W20615695851 @default.
- W2061569585 hasConcept C104317684 @default.
- W2061569585 hasConcept C111599444 @default.
- W2061569585 hasConcept C171958077 @default.
- W2061569585 hasConcept C203014093 @default.
- W2061569585 hasConcept C22615655 @default.
- W2061569585 hasConcept C2776178377 @default.
- W2061569585 hasConcept C2777658100 @default.
- W2061569585 hasConcept C2777701055 @default.
- W2061569585 hasConcept C2778923194 @default.
- W2061569585 hasConcept C2780674031 @default.
- W2061569585 hasConcept C32470452 @default.
- W2061569585 hasConcept C40767141 @default.
- W2061569585 hasConcept C502942594 @default.
- W2061569585 hasConcept C54009773 @default.
- W2061569585 hasConcept C54355233 @default.
- W2061569585 hasConcept C55493867 @default.
- W2061569585 hasConcept C62478195 @default.
- W2061569585 hasConcept C71924100 @default.
- W2061569585 hasConcept C81885089 @default.
- W2061569585 hasConcept C86803240 @default.
- W2061569585 hasConcept C8891405 @default.
- W2061569585 hasConcept C95444343 @default.
- W2061569585 hasConceptScore W2061569585C104317684 @default.
- W2061569585 hasConceptScore W2061569585C111599444 @default.
- W2061569585 hasConceptScore W2061569585C171958077 @default.
- W2061569585 hasConceptScore W2061569585C203014093 @default.
- W2061569585 hasConceptScore W2061569585C22615655 @default.
- W2061569585 hasConceptScore W2061569585C2776178377 @default.