Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061570249> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2061570249 endingPage "73" @default.
- W2061570249 startingPage "71" @default.
- W2061570249 abstract "Drug resistance is a key contributor for treatment failure in hematologic and other malignancies. Nilotinib has been observed with significant activity in patients with chronic phase chronic myeloid leukemia (CML) who have failed or are intolerant of imatinib therapy. Recent reports have suggested that microRNA (miRNA) expression changes are involved in the drug response of human cancer. Several miRNAs have been previously found to be consistently deregulated in imatinib resistance; however, very limited information is available for nilotinib-treated patients who have failed imatinib therapy. Many reports have discovered circulating miRNAs as noninvasive biomarkers of disease and therapy response. The aim of this study was to explore miRNA regulation and find candidate miRNA markers for CML that can be used for drug response prediction. Here we demonstrate the circulating miRNA profile in the culture supernatant of imatinib-resistant K562 CML cells (K562-R) by microarray chip analysis. We have identified specific miRNAs that are associated with nilotinib sensitivity by comparison of miRNA expression patterns from the culture supernatant of nilotinib-treated K562-R cells with the culture supernatant of untreated K562-R cells. The information obtained from this study may have the potential to become a novel biomarker to predict drug response in the future and can also be applied to developing novel therapeutic treatment for CML." @default.
- W2061570249 created "2016-06-24" @default.
- W2061570249 creator A5005769924 @default.
- W2061570249 creator A5050295640 @default.
- W2061570249 creator A5055079948 @default.
- W2061570249 creator A5062339444 @default.
- W2061570249 date "2013-09-01" @default.
- W2061570249 modified "2023-10-18" @default.
- W2061570249 title "Identification of nilotinib-altered microRNA expression patterns in imatinib-resistant chronic myeloid leukemia cells" @default.
- W2061570249 cites W1977508777 @default.
- W2061570249 cites W1986756287 @default.
- W2061570249 cites W2013642139 @default.
- W2061570249 cites W2051365668 @default.
- W2061570249 cites W2063770678 @default.
- W2061570249 cites W2077393126 @default.
- W2061570249 cites W2107268345 @default.
- W2061570249 cites W2110753217 @default.
- W2061570249 cites W2126235458 @default.
- W2061570249 cites W2126363540 @default.
- W2061570249 cites W2158341077 @default.
- W2061570249 cites W2169658834 @default.
- W2061570249 cites W3146360245 @default.
- W2061570249 doi "https://doi.org/10.1016/j.bgm.2013.07.002" @default.
- W2061570249 hasPublicationYear "2013" @default.
- W2061570249 type Work @default.
- W2061570249 sameAs 2061570249 @default.
- W2061570249 citedByCount "1" @default.
- W2061570249 countsByYear W20615702492015 @default.
- W2061570249 crossrefType "journal-article" @default.
- W2061570249 hasAuthorship W2061570249A5005769924 @default.
- W2061570249 hasAuthorship W2061570249A5050295640 @default.
- W2061570249 hasAuthorship W2061570249A5055079948 @default.
- W2061570249 hasAuthorship W2061570249A5062339444 @default.
- W2061570249 hasConcept C104317684 @default.
- W2061570249 hasConcept C114851261 @default.
- W2061570249 hasConcept C143998085 @default.
- W2061570249 hasConcept C145059251 @default.
- W2061570249 hasConcept C150194340 @default.
- W2061570249 hasConcept C171122931 @default.
- W2061570249 hasConcept C186836561 @default.
- W2061570249 hasConcept C203014093 @default.
- W2061570249 hasConcept C2777413986 @default.
- W2061570249 hasConcept C2777583451 @default.
- W2061570249 hasConcept C2778461978 @default.
- W2061570249 hasConcept C2778729363 @default.
- W2061570249 hasConcept C2781197716 @default.
- W2061570249 hasConcept C3019892230 @default.
- W2061570249 hasConcept C502942594 @default.
- W2061570249 hasConcept C55493867 @default.
- W2061570249 hasConcept C71924100 @default.
- W2061570249 hasConcept C86803240 @default.
- W2061570249 hasConcept C89423630 @default.
- W2061570249 hasConcept C98274493 @default.
- W2061570249 hasConceptScore W2061570249C104317684 @default.
- W2061570249 hasConceptScore W2061570249C114851261 @default.
- W2061570249 hasConceptScore W2061570249C143998085 @default.
- W2061570249 hasConceptScore W2061570249C145059251 @default.
- W2061570249 hasConceptScore W2061570249C150194340 @default.
- W2061570249 hasConceptScore W2061570249C171122931 @default.
- W2061570249 hasConceptScore W2061570249C186836561 @default.
- W2061570249 hasConceptScore W2061570249C203014093 @default.
- W2061570249 hasConceptScore W2061570249C2777413986 @default.
- W2061570249 hasConceptScore W2061570249C2777583451 @default.
- W2061570249 hasConceptScore W2061570249C2778461978 @default.
- W2061570249 hasConceptScore W2061570249C2778729363 @default.
- W2061570249 hasConceptScore W2061570249C2781197716 @default.
- W2061570249 hasConceptScore W2061570249C3019892230 @default.
- W2061570249 hasConceptScore W2061570249C502942594 @default.
- W2061570249 hasConceptScore W2061570249C55493867 @default.
- W2061570249 hasConceptScore W2061570249C71924100 @default.
- W2061570249 hasConceptScore W2061570249C86803240 @default.
- W2061570249 hasConceptScore W2061570249C89423630 @default.
- W2061570249 hasConceptScore W2061570249C98274493 @default.
- W2061570249 hasFunder F4320321040 @default.
- W2061570249 hasFunder F4320326425 @default.
- W2061570249 hasIssue "3" @default.
- W2061570249 hasLocation W20615702491 @default.
- W2061570249 hasOpenAccess W2061570249 @default.
- W2061570249 hasPrimaryLocation W20615702491 @default.
- W2061570249 hasRelatedWork W2032062312 @default.
- W2061570249 hasRelatedWork W2061493553 @default.
- W2061570249 hasRelatedWork W2061570249 @default.
- W2061570249 hasRelatedWork W2134832378 @default.
- W2061570249 hasRelatedWork W2269568855 @default.
- W2061570249 hasRelatedWork W2306349432 @default.
- W2061570249 hasRelatedWork W2387857109 @default.
- W2061570249 hasRelatedWork W2623745898 @default.
- W2061570249 hasRelatedWork W2983751648 @default.
- W2061570249 hasRelatedWork W3137066459 @default.
- W2061570249 hasVolume "5" @default.
- W2061570249 isParatext "false" @default.
- W2061570249 isRetracted "false" @default.
- W2061570249 magId "2061570249" @default.
- W2061570249 workType "article" @default.