FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061571837> ?p ?o ?g. }

• W2061571837 endingPage "183" @default.
• W2061571837 startingPage "178" @default.
• W2061571837 abstract "Recent clinical reports found a high incidence of recurrent otitis media in children suffering hyperacusis, a marked intolerance to an otherwise ordinary environmental sound. However, it is unclear whether the conductive hearing loss caused by otitis media in early age will affect sound tolerance later in life. Thus, we have tested the effects of tympanic membrane (TM) damage at an early age on sound perception development in rats. Two weeks after the TM perforation, more than 80% of the rats showed audiogenic seizure (AGS) when exposed to loud sound (120 dB SPL white noise, < 1 min). The susceptibility of AGS lasted at least sixteen weeks after the TM damage, even the hearing loss recovered. The TM damaged rats also showed significantly enhanced acoustic startle responses compared to the rats without TM damage. These results suggest that early age conductive hearing loss may cause an impaired sound tolerance during development. In addition, the AGS can be suppressed by the treatment of vigabatrin, acute injections (250 mg/kg) or oral intakes (60 mg/kg/day for 7 days), an antiepileptic drug that inhibits the catabolism of GABA. c-Fos staining showed a strong staining in the inferior colliculus (IC) in the TM damaged rats, not in the control rats, after exposed to loud sound, indicating a hyper-excitability in the IC during AGS. These results indicate that early age conductive hearing loss can impair sound tolerance by reducing GABA inhibition in the IC, which may be related to hyperacusis seen in children with otitis media." @default.
• W2061571837 created "2016-06-24" @default.
• W2061571837 creator A5024945324 @default.
• W2061571837 creator A5026567678 @default.
• W2061571837 creator A5035159183 @default.
• W2061571837 creator A5052405691 @default.
• W2061571837 creator A5060953840 @default.
• W2061571837 creator A5064803348 @default.
• W2061571837 creator A5073481800 @default.
• W2061571837 date "2011-12-01" @default.
• W2061571837 modified "2023-09-23" @default.
• W2061571837 title "Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior" @default.
• W2061571837 cites W148074354 @default.
• W2061571837 cites W1524382456 @default.
• W2061571837 cites W1886767962 @default.
• W2061571837 cites W1967205888 @default.
• W2061571837 cites W1968669108 @default.
• W2061571837 cites W1974562572 @default.
• W2061571837 cites W1989703387 @default.
• W2061571837 cites W1989771497 @default.
• W2061571837 cites W1992618627 @default.
• W2061571837 cites W2005122845 @default.
• W2061571837 cites W2023097378 @default.
• W2061571837 cites W2038085920 @default.
• W2061571837 cites W2041661978 @default.
• W2061571837 cites W2045875692 @default.
• W2061571837 cites W2048301503 @default.
• W2061571837 cites W2053516515 @default.
• W2061571837 cites W2056733547 @default.
• W2061571837 cites W2072141159 @default.
• W2061571837 cites W2072528485 @default.
• W2061571837 cites W2074149569 @default.
• W2061571837 cites W2079025555 @default.
• W2061571837 cites W2080768569 @default.
• W2061571837 cites W2083350842 @default.
• W2061571837 cites W2083975192 @default.
• W2061571837 cites W2087390900 @default.
• W2061571837 cites W2092180954 @default.
• W2061571837 cites W2104466105 @default.
• W2061571837 cites W2111202988 @default.
• W2061571837 cites W2115209748 @default.
• W2061571837 cites W2139731089 @default.
• W2061571837 cites W2144771100 @default.
• W2061571837 cites W2150405052 @default.
• W2061571837 cites W2164766378 @default.
• W2061571837 doi "https://doi.org/10.1016/j.heares.2011.08.004" @default.
• W2061571837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3230688" @default.
• W2061571837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21872651" @default.
• W2061571837 hasPublicationYear "2011" @default.
• W2061571837 type Work @default.
• W2061571837 sameAs 2061571837 @default.
• W2061571837 citedByCount "29" @default.
• W2061571837 countsByYear W20615718372012 @default.
• W2061571837 countsByYear W20615718372013 @default.
• W2061571837 countsByYear W20615718372014 @default.
• W2061571837 countsByYear W20615718372015 @default.
• W2061571837 countsByYear W20615718372016 @default.
• W2061571837 countsByYear W20615718372017 @default.
• W2061571837 countsByYear W20615718372018 @default.
• W2061571837 countsByYear W20615718372019 @default.
• W2061571837 countsByYear W20615718372020 @default.
• W2061571837 countsByYear W20615718372021 @default.
• W2061571837 countsByYear W20615718372022 @default.
• W2061571837 countsByYear W20615718372023 @default.
• W2061571837 crossrefType "journal-article" @default.
• W2061571837 hasAuthorship W2061571837A5024945324 @default.
• W2061571837 hasAuthorship W2061571837A5026567678 @default.
• W2061571837 hasAuthorship W2061571837A5035159183 @default.
• W2061571837 hasAuthorship W2061571837A5052405691 @default.
• W2061571837 hasAuthorship W2061571837A5060953840 @default.
• W2061571837 hasAuthorship W2061571837A5064803348 @default.
• W2061571837 hasAuthorship W2061571837A5073481800 @default.
• W2061571837 hasBestOaLocation W20615718372 @default.
• W2061571837 hasConcept C118552586 @default.
• W2061571837 hasConcept C141071460 @default.
• W2061571837 hasConcept C2775980177 @default.
• W2061571837 hasConcept C2776439223 @default.
• W2061571837 hasConcept C2777939402 @default.
• W2061571837 hasConcept C2779260231 @default.
• W2061571837 hasConcept C2780493683 @default.
• W2061571837 hasConcept C2780723820 @default.
• W2061571837 hasConcept C548259974 @default.
• W2061571837 hasConcept C71924100 @default.
• W2061571837 hasConceptScore W2061571837C118552586 @default.
• W2061571837 hasConceptScore W2061571837C141071460 @default.
• W2061571837 hasConceptScore W2061571837C2775980177 @default.
• W2061571837 hasConceptScore W2061571837C2776439223 @default.
• W2061571837 hasConceptScore W2061571837C2777939402 @default.
• W2061571837 hasConceptScore W2061571837C2779260231 @default.
• W2061571837 hasConceptScore W2061571837C2780493683 @default.
• W2061571837 hasConceptScore W2061571837C2780723820 @default.
• W2061571837 hasConceptScore W2061571837C548259974 @default.
• W2061571837 hasConceptScore W2061571837C71924100 @default.
• W2061571837 hasIssue "1-2" @default.
• W2061571837 hasLocation W20615718371 @default.
• W2061571837 hasLocation W20615718372 @default.
• W2061571837 hasLocation W20615718373 @default.
• W2061571837 hasLocation W20615718374 @default.

• next