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- W2061572162 abstract "The effects of sodium bicarbonate and Carbicarb (International Medical Systems, South El Monte, CA) infusions on hemodynamic and systemic acid-base homeostasis were compared in six normal volunteers. Neither sodium bicarbonate nor Carbicarb caused any major adverse side effects or had a significant effect on heart rate and blood pressure. However, during the first 3 minutes following infusion, sodium bicarbonate induced marked increases in respiratory carbon dioxide excretion above baseline (▴VCO2) compared with Carbicarb (+0.61 ± 0.10 v +0.01 ± 0.10 mmol/kg, P < .01) and increases in PaCO2, whereas Carbicarb was associated with a transient decrease in PaCO2 (+11.8 ± 1.6v −5.0 ± .8 mm Hg, P < .01). We calculated that approximately 31% of sodium bicarbonate, but virtually no Carbicarb, was excreted as expired CO2. These data suggest that if used clinically, Carbicarb therapy might not be associated with the deleterious effects of sodium bicarbonate that are postulated to result from CO2 generation." @default.
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- W2061572162 date "1990-09-01" @default.
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- W2061572162 title "Different effects of sodium bicarbonate and an alternate buffer (Carbicarb) in normal volunteers" @default.
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- W2061572162 doi "https://doi.org/10.1016/0883-9441(90)90036-9" @default.
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