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- W2061585193 abstract "Ulcerative colitis (UC) and Crohn's disease (CD) are related polygenic inflammatory bowel diseases (IBDs), with distinct and overlapping susceptibility loci. Recently, hypothesis-free genome-wide association (GWA) studies have revolutionized the field of complex disease genetics. Substantial advances have been achieved in defining the genetic architecture of IBD. To date, over 60 published IBD susceptibility loci have been discovered and replicated, of which approximately a third are associated with both UC and CD, although 21 are specific to UC and 23 to CD. In CD, the breakthrough identification of NOD2 as a susceptibility gene was followed by a rapid phase of gene discovery from GWA studies between 2006 and 2008. Progress in UC was slower; however, by initially testing hits for CD in UC, and later scanning larger UC cohorts, significant new loci for UC have been discovered, with exciting novel insights into disease pathogenesis. Notably, genes implicated in mucosal barrier function (ECM1, CDH1, HNF4α, and laminin B1) confer risk of UC; furthermore, E-cadherin is the first genetic correlation between colorectal cancer and UC. Impaired IL10 signaling has reemerged as a key pathway in intestinal inflammation, and is perhaps the most amenable to therapeutic intervention in UC. Collaborative international efforts with large meta-analyses of GWA studies and replication will yield many new UC genes. Furthermore, a large effort is required to characterize the loci found. Fine-mapping, deep resequencing, and functional studies will be critical to translating these gene discoveries into pathogenic insights, and ultimately into clinical insights and novel therapeutics. (Inflamm Bowel Dis 2011;)" @default.
- W2061585193 created "2016-06-24" @default.
- W2061585193 creator A5005142341 @default.
- W2061585193 creator A5020761752 @default.
- W2061585193 date "2011-03-01" @default.
- W2061585193 modified "2023-10-09" @default.
- W2061585193 title "Genetics of ulcerative colitis" @default.
- W2061585193 cites W1480238487 @default.
- W2061585193 cites W1487976653 @default.
- W2061585193 cites W1490277221 @default.
- W2061585193 cites W1571884451 @default.
- W2061585193 cites W1574069719 @default.
- W2061585193 cites W1642457845 @default.
- W2061585193 cites W1670573097 @default.
- W2061585193 cites W1670771883 @default.
- W2061585193 cites W1966680659 @default.
- W2061585193 cites W1968067289 @default.
- W2061585193 cites W1969465117 @default.
- W2061585193 cites W1970571999 @default.
- W2061585193 cites W1980370120 @default.
- W2061585193 cites W1981714996 @default.
- W2061585193 cites W1987056970 @default.
- W2061585193 cites W1987628377 @default.
- W2061585193 cites W1989581181 @default.
- W2061585193 cites W1990701314 @default.
- W2061585193 cites W1993879259 @default.
- W2061585193 cites W1996144078 @default.
- W2061585193 cites W1999750427 @default.
- W2061585193 cites W2002124107 @default.
- W2061585193 cites W2004802907 @default.
- W2061585193 cites W2005739512 @default.
- W2061585193 cites W2006249161 @default.
- W2061585193 cites W2010203932 @default.
- W2061585193 cites W2013197667 @default.
- W2061585193 cites W2013873874 @default.
- W2061585193 cites W2016074710 @default.
- W2061585193 cites W2016205873 @default.
- W2061585193 cites W2017329964 @default.
- W2061585193 cites W2017443683 @default.
- W2061585193 cites W2019156031 @default.
- W2061585193 cites W2019300181 @default.
- W2061585193 cites W2020233428 @default.
- W2061585193 cites W2020522891 @default.
- W2061585193 cites W2021706207 @default.
- W2061585193 cites W2022898802 @default.
- W2061585193 cites W2027350554 @default.
- W2061585193 cites W2027586189 @default.
- W2061585193 cites W2028251031 @default.
- W2061585193 cites W2028402416 @default.
- W2061585193 cites W2028763115 @default.
- W2061585193 cites W2029425169 @default.
- W2061585193 cites W2030784582 @default.
- W2061585193 cites W2031035500 @default.
- W2061585193 cites W2032025006 @default.
- W2061585193 cites W2033276039 @default.
- W2061585193 cites W2036500213 @default.
- W2061585193 cites W2043647235 @default.
- W2061585193 cites W2043760494 @default.
- W2061585193 cites W2044584260 @default.
- W2061585193 cites W2046579578 @default.
- W2061585193 cites W2049946738 @default.
- W2061585193 cites W2050069938 @default.
- W2061585193 cites W2052330087 @default.
- W2061585193 cites W2054176565 @default.
- W2061585193 cites W2054802177 @default.
- W2061585193 cites W2060160394 @default.
- W2061585193 cites W2060546545 @default.
- W2061585193 cites W2061783703 @default.
- W2061585193 cites W2063490880 @default.
- W2061585193 cites W2066032613 @default.
- W2061585193 cites W2067652054 @default.
- W2061585193 cites W2067922543 @default.
- W2061585193 cites W2068750178 @default.
- W2061585193 cites W2069968649 @default.
- W2061585193 cites W2070436145 @default.
- W2061585193 cites W2071073523 @default.
- W2061585193 cites W2073869570 @default.
- W2061585193 cites W2076028713 @default.
- W2061585193 cites W2076242748 @default.
- W2061585193 cites W2076781851 @default.
- W2061585193 cites W2076889715 @default.
- W2061585193 cites W2077925418 @default.
- W2061585193 cites W2078621117 @default.
- W2061585193 cites W2079077914 @default.
- W2061585193 cites W2080195364 @default.
- W2061585193 cites W2080248549 @default.
- W2061585193 cites W2080702126 @default.
- W2061585193 cites W2081330723 @default.
- W2061585193 cites W2083681924 @default.
- W2061585193 cites W2084798149 @default.
- W2061585193 cites W2084990572 @default.
- W2061585193 cites W2085110576 @default.
- W2061585193 cites W2087905758 @default.
- W2061585193 cites W2088449391 @default.
- W2061585193 cites W2089983507 @default.
- W2061585193 cites W2090197666 @default.
- W2061585193 cites W2090198994 @default.
- W2061585193 cites W2091457240 @default.