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- W2061594552 abstract "Abstract In starved and fed rats having received single intraperitoneal injections of 25 mg/kg chlorpromazine, of 2 mg/kg reserpine, and of 100 mg/kg phenobarbital respectively, the level of glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate dihydroxyacetone phosphate, adenosine 5'-triphosphate (ATP), inorganic phosphate, and glycogen was estimated in blood and brain. In the brain, but not in the blood, the three drugs decreased glucose-6-phosphate and fructose-6-phosphate at the time of maximal depression of the motor activity. The other phosphorylated metabolites as well as the inorganic phosphate showed no regular alterations. Reserpine and phenobarbital, but not chlorpromazine, caused an accumulation of glycogen following the time of maximal sedation. The finding of decreased hexose phosphates in the brain supports the hypothesis that central depressant drugs suppress glycolysis in the central nervous system in vivo possibly by a diminution of glucose phosphorylation." @default.
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- W2061594552 date "1965-04-01" @default.
- W2061594552 modified "2023-09-27" @default.
- W2061594552 title "Suppression of glycolysis in rat brain in vivo by chlorpromazine, reserpine, and phenobarbital" @default.
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- W2061594552 doi "https://doi.org/10.1016/0006-2952(65)90223-6" @default.
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