Matches in SemOpenAlex for { <https://semopenalex.org/work/W206160930> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W206160930 endingPage "368" @default.
- W206160930 startingPage "355" @default.
- W206160930 abstract "SummaryAntineutrophil cytoplasmic antibody (c-ANCA) has a reported sensitivity and specificity greater than 90% for active Wegener's granulomatosis in selected patients with previously-defined disease. Because of these reports, some clinicians believe that a positive c-ANCA result provides strong circumstantial evidence for the diagnosis of Wegener's granulomatosis in patients with compatible clinical symptoms. However, this approach has not been examined prospectively.We prospectively studied 346 consecutive patients suspected of having vasculitis; those with previously established Wegener's granulomatosis (n=29) or receiving immunosuppressives other than corticosteroids (n=65) at baseline were excluded. Measures included a baseline c-ANCA, blinded chart reviews to record symptoms, physical findings, and corticosteroid use at baseline, and 2 to 8 months later to record final diagnoses and biopsy results. Wegener's granulomatosis was defined using the 1990 American College of Rheumatology (ACR) criteria, which does not require a biopsy. Follow-up information was available for 212 (84%) of the 252 patients eligible for this study (no corticosteroids: n=174; corticosteroids: n=78). 25 patients with compatible symptoms were classified with Wegener's granulomatosis by ACR criteria; only 6 of the 25 had biopsy-proven disease. 14 of these 212 patients had positive c-ANCA results. The overall sensitivity and specificity of c-ANCA for ACR-defined Wegener'sgranulomatosis were 28% (95% Cl, 10%-46%) and 96% (93%-99%) respectively. The positive and negative predictive values were 0·50 and 0·91. The specificity remained greater than 90% regardless of baseline corticosteroid use or disease activity; however, the sensitivity and positive predictive value remained poor. For Wegener's granulomatosis defined by biopsy criteria and compatible clinical symptoms, the sensitivity was 83% (53%-100%); however, the positive predictive value was 36%.These results raise serious questions about the use of positive c-ANCA tests in diagnosing Wegener's granulomatosis in patients with clinical symptoms alone." @default.
- W206160930 created "2016-06-24" @default.
- W206160930 creator A5031736334 @default.
- W206160930 creator A5046765835 @default.
- W206160930 creator A5075603708 @default.
- W206160930 date "1986-03-01" @default.
- W206160930 modified "2023-09-26" @default.
- W206160930 title "Diagnostic and Therapeutic Approach to the Patient with Vasculitis" @default.
- W206160930 cites W145446037 @default.
- W206160930 cites W18245770 @default.
- W206160930 cites W1979363802 @default.
- W206160930 cites W1981305931 @default.
- W206160930 cites W1985622331 @default.
- W206160930 cites W1998717993 @default.
- W206160930 cites W2011485291 @default.
- W206160930 cites W2036503292 @default.
- W206160930 cites W2065151323 @default.
- W206160930 cites W2070655720 @default.
- W206160930 cites W2076820601 @default.
- W206160930 cites W2076863034 @default.
- W206160930 cites W2080221134 @default.
- W206160930 cites W2109207289 @default.
- W206160930 cites W2168620318 @default.
- W206160930 cites W2312254946 @default.
- W206160930 cites W2341719812 @default.
- W206160930 cites W4241993342 @default.
- W206160930 doi "https://doi.org/10.1016/s0025-7125(16)30958-0" @default.
- W206160930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3951269" @default.
- W206160930 hasPublicationYear "1986" @default.
- W206160930 type Work @default.
- W206160930 sameAs 206160930 @default.
- W206160930 citedByCount "20" @default.
- W206160930 countsByYear W2061609302020 @default.
- W206160930 countsByYear W2061609302022 @default.
- W206160930 crossrefType "journal-article" @default.
- W206160930 hasAuthorship W206160930A5031736334 @default.
- W206160930 hasAuthorship W206160930A5046765835 @default.
- W206160930 hasAuthorship W206160930A5075603708 @default.
- W206160930 hasConcept C126322002 @default.
- W206160930 hasConcept C142724271 @default.
- W206160930 hasConcept C16005928 @default.
- W206160930 hasConcept C188816634 @default.
- W206160930 hasConcept C198451711 @default.
- W206160930 hasConcept C24040308 @default.
- W206160930 hasConcept C2775934546 @default.
- W206160930 hasConcept C2776015282 @default.
- W206160930 hasConcept C2776804153 @default.
- W206160930 hasConcept C2779134260 @default.
- W206160930 hasConcept C534262118 @default.
- W206160930 hasConcept C71924100 @default.
- W206160930 hasConcept C90924648 @default.
- W206160930 hasConceptScore W206160930C126322002 @default.
- W206160930 hasConceptScore W206160930C142724271 @default.
- W206160930 hasConceptScore W206160930C16005928 @default.
- W206160930 hasConceptScore W206160930C188816634 @default.
- W206160930 hasConceptScore W206160930C198451711 @default.
- W206160930 hasConceptScore W206160930C24040308 @default.
- W206160930 hasConceptScore W206160930C2775934546 @default.
- W206160930 hasConceptScore W206160930C2776015282 @default.
- W206160930 hasConceptScore W206160930C2776804153 @default.
- W206160930 hasConceptScore W206160930C2779134260 @default.
- W206160930 hasConceptScore W206160930C534262118 @default.
- W206160930 hasConceptScore W206160930C71924100 @default.
- W206160930 hasConceptScore W206160930C90924648 @default.
- W206160930 hasIssue "2" @default.
- W206160930 hasLocation W2061609301 @default.
- W206160930 hasLocation W2061609302 @default.
- W206160930 hasOpenAccess W206160930 @default.
- W206160930 hasPrimaryLocation W2061609301 @default.
- W206160930 hasRelatedWork W1977125177 @default.
- W206160930 hasRelatedWork W1996232081 @default.
- W206160930 hasRelatedWork W2015024762 @default.
- W206160930 hasRelatedWork W2081370509 @default.
- W206160930 hasRelatedWork W2738342291 @default.
- W206160930 hasRelatedWork W2752775514 @default.
- W206160930 hasRelatedWork W3006168661 @default.
- W206160930 hasRelatedWork W3190421869 @default.
- W206160930 hasRelatedWork W4200524844 @default.
- W206160930 hasRelatedWork W4282914536 @default.
- W206160930 hasVolume "70" @default.
- W206160930 isParatext "false" @default.
- W206160930 isRetracted "false" @default.
- W206160930 magId "206160930" @default.
- W206160930 workType "article" @default.