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- W2061619697 abstract "Adenylosuccinate lyase deficiency, which is associated with severe mental retardation and autistic features, was discovered in 1984. Since then this enzyme has been analyzed in many human tissues and it is now generally agreed that screening for this enzyme defect should be performed in all unexplained neurological diseases. The aim of the present study was to analyze adenylosuccinate lyase activity in blood cells by a fast simple method adaptable to screening purposes. The activity was also analyzed in B-lymphocytes from patients with B-cell chronic lymphocytic leukemia. The biological role of adenylosuccinate lyase and its importance in regulating cellular levels of AMP is discussed." @default.
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- W2061619697 date "2001-06-01" @default.
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- W2061619697 title "Determination, activity and biological role of adenylosuccinate lyase in blood cells" @default.
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- W2061619697 doi "https://doi.org/10.1016/s0753-3322(01)00061-0" @default.
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