Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061620964> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2061620964 endingPage "3277" @default.
- W2061620964 startingPage "3266" @default.
- W2061620964 abstract "Tricarbonylation of clarithromycin has been effected in a one-pot reaction with phosgene. The 11,12-diol moiety was closed into a cyclic carbonate, while the dimethylamino alcohol of the desosamine sugar was cyclised with loss of a methyl group to form a cyclic 2',3'-carbamate. The 4'' hydroxyl group in clarithromycin was converted into a chloroformate group and subsequently to an allyl carbonate which on Pd-catalysis furnished a novel N-demethylclarithromycin 2',3'-carbamate-11,12-carbonate. Hydrolytic removal of the cladinose sugar and a subsequent oxidation furnished the corresponding ketolide. The 11,12-cyclic carbonate moiety was cleaved by sodium azide to the 10,11-anhydro-9-ketone. 11-N-Arylated cyclic 11,12:2',3'-dicarbamate derivatives were prepared in a copper(I) chloride aided reaction between aryl isocyanates and 10,11-anhydro 9-ketones. The products are novel N-arylated-N'-demethylated 11,12:2',3'-dicarbamate ketolides derived from clarithromycin." @default.
- W2061620964 created "2016-06-24" @default.
- W2061620964 creator A5027468732 @default.
- W2061620964 creator A5054484904 @default.
- W2061620964 date "2007-05-01" @default.
- W2061620964 modified "2023-10-04" @default.
- W2061620964 title "Preparation of cyclic 2′,3′-carbamate derivatives of erythromycin macrolide antibiotics" @default.
- W2061620964 cites W170633719 @default.
- W2061620964 cites W1965534767 @default.
- W2061620964 cites W1967408737 @default.
- W2061620964 cites W1969989376 @default.
- W2061620964 cites W1970211626 @default.
- W2061620964 cites W1970561727 @default.
- W2061620964 cites W1975010229 @default.
- W2061620964 cites W1977936424 @default.
- W2061620964 cites W1994160110 @default.
- W2061620964 cites W2004974679 @default.
- W2061620964 cites W2009448652 @default.
- W2061620964 cites W2017010082 @default.
- W2061620964 cites W2017013022 @default.
- W2061620964 cites W2017500544 @default.
- W2061620964 cites W2019306390 @default.
- W2061620964 cites W2032629748 @default.
- W2061620964 cites W2037157460 @default.
- W2061620964 cites W2039326290 @default.
- W2061620964 cites W2048619259 @default.
- W2061620964 cites W2055848085 @default.
- W2061620964 cites W2058623521 @default.
- W2061620964 cites W2058911988 @default.
- W2061620964 cites W2059725683 @default.
- W2061620964 cites W2073834854 @default.
- W2061620964 cites W2076031042 @default.
- W2061620964 cites W2096573038 @default.
- W2061620964 cites W2140424229 @default.
- W2061620964 cites W2166117980 @default.
- W2061620964 cites W2168635615 @default.
- W2061620964 cites W2170337204 @default.
- W2061620964 cites W2326771724 @default.
- W2061620964 cites W2327617835 @default.
- W2061620964 cites W4235212353 @default.
- W2061620964 doi "https://doi.org/10.1016/j.bmc.2007.02.028" @default.
- W2061620964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17337343" @default.
- W2061620964 hasPublicationYear "2007" @default.
- W2061620964 type Work @default.
- W2061620964 sameAs 2061620964 @default.
- W2061620964 citedByCount "14" @default.
- W2061620964 countsByYear W20616209642012 @default.
- W2061620964 countsByYear W20616209642013 @default.
- W2061620964 countsByYear W20616209642016 @default.
- W2061620964 countsByYear W20616209642018 @default.
- W2061620964 crossrefType "journal-article" @default.
- W2061620964 hasAuthorship W2061620964A5027468732 @default.
- W2061620964 hasAuthorship W2061620964A5054484904 @default.
- W2061620964 hasConcept C155647269 @default.
- W2061620964 hasConcept C178790620 @default.
- W2061620964 hasConcept C185592680 @default.
- W2061620964 hasConcept C2776568683 @default.
- W2061620964 hasConcept C2777738585 @default.
- W2061620964 hasConcept C2778704027 @default.
- W2061620964 hasConcept C2779303437 @default.
- W2061620964 hasConcept C2780071497 @default.
- W2061620964 hasConcept C2780997848 @default.
- W2061620964 hasConcept C2781066024 @default.
- W2061620964 hasConcept C2781417787 @default.
- W2061620964 hasConceptScore W2061620964C155647269 @default.
- W2061620964 hasConceptScore W2061620964C178790620 @default.
- W2061620964 hasConceptScore W2061620964C185592680 @default.
- W2061620964 hasConceptScore W2061620964C2776568683 @default.
- W2061620964 hasConceptScore W2061620964C2777738585 @default.
- W2061620964 hasConceptScore W2061620964C2778704027 @default.
- W2061620964 hasConceptScore W2061620964C2779303437 @default.
- W2061620964 hasConceptScore W2061620964C2780071497 @default.
- W2061620964 hasConceptScore W2061620964C2780997848 @default.
- W2061620964 hasConceptScore W2061620964C2781066024 @default.
- W2061620964 hasConceptScore W2061620964C2781417787 @default.
- W2061620964 hasIssue "9" @default.
- W2061620964 hasLocation W20616209641 @default.
- W2061620964 hasLocation W20616209642 @default.
- W2061620964 hasOpenAccess W2061620964 @default.
- W2061620964 hasPrimaryLocation W20616209641 @default.
- W2061620964 hasRelatedWork W1991619643 @default.
- W2061620964 hasRelatedWork W2008614075 @default.
- W2061620964 hasRelatedWork W2023281720 @default.
- W2061620964 hasRelatedWork W2070890681 @default.
- W2061620964 hasRelatedWork W2147427301 @default.
- W2061620964 hasRelatedWork W2170127697 @default.
- W2061620964 hasRelatedWork W2198718095 @default.
- W2061620964 hasRelatedWork W2341011754 @default.
- W2061620964 hasRelatedWork W2950931419 @default.
- W2061620964 hasRelatedWork W3015184028 @default.
- W2061620964 hasVolume "15" @default.
- W2061620964 isParatext "false" @default.
- W2061620964 isRetracted "false" @default.
- W2061620964 magId "2061620964" @default.
- W2061620964 workType "article" @default.