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• W2061628657 abstract "The earliest characterized events during induction of tubulogenesis in renal anlage include the condensation or compaction of metanephrogenic mesenchyme with the concurrent upregulation of WT1, the gene encoding the Wilms tumor transcriptional activator/suppressor. We report that basic fibroblast growth factor (FGF2) can mimic the early effects of an inductor tissue by promoting the condensation of mesenchyme and inhibiting the tissue degeneration associated with the absence of an inductor tissue. By in situ hybridization, FGF2 was also found to mediate the transcriptional activation of WT1 and of the hepatocyte growth factor receptor gene, c-met. Although FGF2 can induce these early events of renal tubulogenesis, it cannot promote the epithelial conversion associated with tubule formation in metanephrogenic mesenchyme. For this, an undefined factor(s) from pituitary extract in combination with FGF2 can cause tubule formation in uninduced mesenchyme. These findings support the concept that induction in kidney is a multiphasic process that is mediated by more than a single comprehensive inductive factor and that soluble molecules can mimic these inductive activities in isolated uninduced metanephrogenic mesenchyme." @default.
• W2061628657 created "2016-06-24" @default.
• W2061628657 creator A5022316854 @default.
• W2061628657 creator A5051338590 @default.
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• W2061628657 date "1995-05-09" @default.
• W2061628657 modified "2023-09-23" @default.
• W2061628657 title "Basic fibroblast growth factor can mediate the early inductive events in renal development." @default.
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• W2061628657 doi "https://doi.org/10.1073/pnas.92.10.4696" @default.
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