Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061630657> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2061630657 endingPage "230" @default.
- W2061630657 startingPage "219" @default.
- W2061630657 abstract "Aspirin was developed as a non-steroidal anti-inflammatory drug (NSAID) in 1899. During the century after that, aspirin has been found to show its anti-inflammatory, analgesic and anti-pyretic activities by reducing prostaglandins biosynthesis through inhibition of cyclooxygenase (COX); and then COX was found to be constituted of two isoforms, constitutive COX-1 and inducible COX-2. Currently, novel NSAIDs, acting through selective inhibition of COX-2, that have efficacy as excellent as aspirin with significantly lower incidence of gastrointestinal adverse effects are available in America and some other countries, but not in Japan. Physiological and pathophysiological roles of COX-1 and COX-2 have been explained from studies in experimental animals, but there are many differences in species and diseases between animals and humans. Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development." @default.
- W2061630657 created "2016-06-24" @default.
- W2061630657 creator A5050917634 @default.
- W2061630657 date "2001-01-01" @default.
- W2061630657 modified "2023-09-26" @default.
- W2061630657 title "Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors" @default.
- W2061630657 cites W1968219794 @default.
- W2061630657 cites W1981662925 @default.
- W2061630657 cites W1983104516 @default.
- W2061630657 cites W1987407100 @default.
- W2061630657 cites W1998213501 @default.
- W2061630657 cites W2000795486 @default.
- W2061630657 cites W2014990551 @default.
- W2061630657 cites W2020563114 @default.
- W2061630657 cites W2021313793 @default.
- W2061630657 cites W2033498682 @default.
- W2061630657 cites W2044750065 @default.
- W2061630657 cites W2054456797 @default.
- W2061630657 cites W2062701796 @default.
- W2061630657 cites W2066074947 @default.
- W2061630657 cites W2077018765 @default.
- W2061630657 cites W2100822604 @default.
- W2061630657 cites W2116728057 @default.
- W2061630657 cites W2124678826 @default.
- W2061630657 cites W2146625461 @default.
- W2061630657 cites W2163756514 @default.
- W2061630657 cites W2164290354 @default.
- W2061630657 cites W2318599684 @default.
- W2061630657 cites W2330496155 @default.
- W2061630657 cites W2336169581 @default.
- W2061630657 cites W4253810669 @default.
- W2061630657 doi "https://doi.org/10.1254/fpj.118.219" @default.
- W2061630657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11577463" @default.
- W2061630657 hasPublicationYear "2001" @default.
- W2061630657 type Work @default.
- W2061630657 sameAs 2061630657 @default.
- W2061630657 citedByCount "5" @default.
- W2061630657 countsByYear W20616306572018 @default.
- W2061630657 countsByYear W20616306572021 @default.
- W2061630657 countsByYear W20616306572023 @default.
- W2061630657 crossrefType "journal-article" @default.
- W2061630657 hasAuthorship W2061630657A5050917634 @default.
- W2061630657 hasBestOaLocation W20616306571 @default.
- W2061630657 hasConcept C121608353 @default.
- W2061630657 hasConcept C126322002 @default.
- W2061630657 hasConcept C181199279 @default.
- W2061630657 hasConcept C185592680 @default.
- W2061630657 hasConcept C197934379 @default.
- W2061630657 hasConcept C2776467144 @default.
- W2061630657 hasConcept C2776914184 @default.
- W2061630657 hasConcept C2777456732 @default.
- W2061630657 hasConcept C2777628954 @default.
- W2061630657 hasConcept C2778484676 @default.
- W2061630657 hasConcept C2778582115 @default.
- W2061630657 hasConcept C2779689624 @default.
- W2061630657 hasConcept C526805850 @default.
- W2061630657 hasConcept C55493867 @default.
- W2061630657 hasConcept C71924100 @default.
- W2061630657 hasConcept C98274493 @default.
- W2061630657 hasConceptScore W2061630657C121608353 @default.
- W2061630657 hasConceptScore W2061630657C126322002 @default.
- W2061630657 hasConceptScore W2061630657C181199279 @default.
- W2061630657 hasConceptScore W2061630657C185592680 @default.
- W2061630657 hasConceptScore W2061630657C197934379 @default.
- W2061630657 hasConceptScore W2061630657C2776467144 @default.
- W2061630657 hasConceptScore W2061630657C2776914184 @default.
- W2061630657 hasConceptScore W2061630657C2777456732 @default.
- W2061630657 hasConceptScore W2061630657C2777628954 @default.
- W2061630657 hasConceptScore W2061630657C2778484676 @default.
- W2061630657 hasConceptScore W2061630657C2778582115 @default.
- W2061630657 hasConceptScore W2061630657C2779689624 @default.
- W2061630657 hasConceptScore W2061630657C526805850 @default.
- W2061630657 hasConceptScore W2061630657C55493867 @default.
- W2061630657 hasConceptScore W2061630657C71924100 @default.
- W2061630657 hasConceptScore W2061630657C98274493 @default.
- W2061630657 hasIssue "3" @default.
- W2061630657 hasLocation W20616306571 @default.
- W2061630657 hasLocation W20616306572 @default.
- W2061630657 hasOpenAccess W2061630657 @default.
- W2061630657 hasPrimaryLocation W20616306571 @default.
- W2061630657 hasRelatedWork W1597512265 @default.
- W2061630657 hasRelatedWork W1979787061 @default.
- W2061630657 hasRelatedWork W1992461121 @default.
- W2061630657 hasRelatedWork W2030213691 @default.
- W2061630657 hasRelatedWork W2030674475 @default.
- W2061630657 hasRelatedWork W2049656865 @default.
- W2061630657 hasRelatedWork W2054769263 @default.
- W2061630657 hasRelatedWork W2061630657 @default.
- W2061630657 hasRelatedWork W2566924688 @default.
- W2061630657 hasRelatedWork W82350142 @default.
- W2061630657 hasVolume "118" @default.
- W2061630657 isParatext "false" @default.
- W2061630657 isRetracted "false" @default.
- W2061630657 magId "2061630657" @default.
- W2061630657 workType "article" @default.