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- W2061635471 abstract "RNA interference (RNAi) is a recently described conserved biological pathway where non-coding RNAs suppress the expression of specific genes. Research efforts in the RNAi field aim to gain a better understanding of how its underlying machinery is orchestrated, to define the biological role of this conserved pathway, determine how to effectively manipulate RNAi in the laboratory and to integrate all this knowledge to develop novel therapies for human disease. This review summarizes the advances in the design of therapeutic RNAi for neurodegenerative diseases and discusses some of the experimental steps required to bring this therapy to human clinical trials." @default.
- W2061635471 created "2016-06-24" @default.
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- W2061635471 date "2006-02-01" @default.
- W2061635471 modified "2023-10-18" @default.
- W2061635471 title "Silencing neurodegenerative disease: bringing RNA interference to the clinic" @default.
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- W2061635471 doi "https://doi.org/10.1586/14737175.6.2.223" @default.
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