Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061651905> ?p ?o ?g. }
- W2061651905 endingPage "52" @default.
- W2061651905 startingPage "43" @default.
- W2061651905 abstract "The activity of the anti-inflammatory agents Flunixin-meglumine (FLU), RS (±) Carprofen (CPF) and S (+) CPF on bovine cyclooxygenases (COXs) has been characterized in feedlot calves using an in vitro whole blood model. The drugs showed equivalent efficacy in their inhibitory activity on COXs, and the rank order of potency for both COX-1 and COX-2 inhibition was FLU > S (+) CPF > RS (±) CPF. Our results indicated that FLU is a nonselective inhibitor of bovine COXs, whereas RS (±) CPF and S (+) CPF exhibited different degrees of preferential inhibition of COX-2 isoenzyme. The rank order of IC50 COX-1: IC50 COX-2 potency ratios was in fact S (+) CPF (51.882) > RS (±) CPF (13.964) > FLU (0.606), and the calculated percentage inhibition of COX-1 corresponding to COX-2 inhibition values comprised between 80% and 95% was comprised between 57.697 and 79.865 for FLU, 33.373 and 51.319 for RS (±) CPF, and 0.230 and 4.622 for S (+) CPF, respectively. These findings are discussed in relation to the prediction of the clinical relevance of COX inhibition by the test drugs in cattle." @default.
- W2061651905 created "2016-06-24" @default.
- W2061651905 creator A5017829476 @default.
- W2061651905 creator A5028272132 @default.
- W2061651905 creator A5038913278 @default.
- W2061651905 creator A5068736681 @default.
- W2061651905 date "2013-04-25" @default.
- W2061651905 modified "2023-09-27" @default.
- W2061651905 title "<i>In vitro</i> enantioselective pharmacodynamics of Carprofen and Flunixin-meglumine in feedlot cattle" @default.
- W2061651905 cites W106832636 @default.
- W2061651905 cites W1928291205 @default.
- W2061651905 cites W1968439879 @default.
- W2061651905 cites W1974613518 @default.
- W2061651905 cites W1986383551 @default.
- W2061651905 cites W1994442506 @default.
- W2061651905 cites W1995082781 @default.
- W2061651905 cites W1998056854 @default.
- W2061651905 cites W2005145329 @default.
- W2061651905 cites W2007187686 @default.
- W2061651905 cites W2008574207 @default.
- W2061651905 cites W2009228494 @default.
- W2061651905 cites W2012810767 @default.
- W2061651905 cites W2018728665 @default.
- W2061651905 cites W2019180215 @default.
- W2061651905 cites W2019370793 @default.
- W2061651905 cites W2020092959 @default.
- W2061651905 cites W2020748749 @default.
- W2061651905 cites W2021120688 @default.
- W2061651905 cites W2021796858 @default.
- W2061651905 cites W2031084334 @default.
- W2061651905 cites W2038410983 @default.
- W2061651905 cites W2052001792 @default.
- W2061651905 cites W2052513825 @default.
- W2061651905 cites W2055394727 @default.
- W2061651905 cites W2058336082 @default.
- W2061651905 cites W2060870413 @default.
- W2061651905 cites W2064812767 @default.
- W2061651905 cites W2066074947 @default.
- W2061651905 cites W2072000048 @default.
- W2061651905 cites W2081741522 @default.
- W2061651905 cites W2081822067 @default.
- W2061651905 cites W2102254877 @default.
- W2061651905 cites W2117064945 @default.
- W2061651905 cites W2125471714 @default.
- W2061651905 cites W2126853519 @default.
- W2061651905 cites W2151534353 @default.
- W2061651905 cites W2156363865 @default.
- W2061651905 cites W2158960911 @default.
- W2061651905 cites W2162311242 @default.
- W2061651905 cites W2162392926 @default.
- W2061651905 cites W2171996143 @default.
- W2061651905 cites W2205478614 @default.
- W2061651905 cites W4237436969 @default.
- W2061651905 doi "https://doi.org/10.1111/jvp.12052" @default.
- W2061651905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23614639" @default.
- W2061651905 hasPublicationYear "2013" @default.
- W2061651905 type Work @default.
- W2061651905 sameAs 2061651905 @default.
- W2061651905 citedByCount "10" @default.
- W2061651905 countsByYear W20616519052015 @default.
- W2061651905 countsByYear W20616519052016 @default.
- W2061651905 countsByYear W20616519052017 @default.
- W2061651905 countsByYear W20616519052018 @default.
- W2061651905 countsByYear W20616519052020 @default.
- W2061651905 countsByYear W20616519052021 @default.
- W2061651905 countsByYear W20616519052022 @default.
- W2061651905 countsByYear W20616519052023 @default.
- W2061651905 crossrefType "journal-article" @default.
- W2061651905 hasAuthorship W2061651905A5017829476 @default.
- W2061651905 hasAuthorship W2061651905A5028272132 @default.
- W2061651905 hasAuthorship W2061651905A5038913278 @default.
- W2061651905 hasAuthorship W2061651905A5068736681 @default.
- W2061651905 hasConcept C109650736 @default.
- W2061651905 hasConcept C111113717 @default.
- W2061651905 hasConcept C112705442 @default.
- W2061651905 hasConcept C181199279 @default.
- W2061651905 hasConcept C185592680 @default.
- W2061651905 hasConcept C202751555 @default.
- W2061651905 hasConcept C2777752497 @default.
- W2061651905 hasConcept C2779689624 @default.
- W2061651905 hasConcept C2780741920 @default.
- W2061651905 hasConcept C526171541 @default.
- W2061651905 hasConcept C55493867 @default.
- W2061651905 hasConcept C57992300 @default.
- W2061651905 hasConcept C71924100 @default.
- W2061651905 hasConcept C98274493 @default.
- W2061651905 hasConceptScore W2061651905C109650736 @default.
- W2061651905 hasConceptScore W2061651905C111113717 @default.
- W2061651905 hasConceptScore W2061651905C112705442 @default.
- W2061651905 hasConceptScore W2061651905C181199279 @default.
- W2061651905 hasConceptScore W2061651905C185592680 @default.
- W2061651905 hasConceptScore W2061651905C202751555 @default.
- W2061651905 hasConceptScore W2061651905C2777752497 @default.
- W2061651905 hasConceptScore W2061651905C2779689624 @default.
- W2061651905 hasConceptScore W2061651905C2780741920 @default.
- W2061651905 hasConceptScore W2061651905C526171541 @default.
- W2061651905 hasConceptScore W2061651905C55493867 @default.
- W2061651905 hasConceptScore W2061651905C57992300 @default.